Calcein MedChemExpress (MCE)

Product Name	Calcein
Synonyms	Calcein CALCEIN CALCEINE Oftasceine CALCEIN, INDICATOR FLUORESCEIN COMPLEXON FLUORESCEIN COMPLEXONE Synonyms Calcein CALCEIN CALCEINE Oftasceine CALCEIN, INDICATOR FLUORESCEIN COMPLEXON FLUORESCEIN COMPLEXONE FLUORESCEIN-METHYLENE-IMINODIACETIC ACID BIS[N,N-BIS(CARBOXYMETHYL)AMINOMETHYL]FLUORESCEIN FLUORESCEIN-2,7-BIS-METHYLIMINODIACETIC SODIUM SALT 2,2',2'',2'''-[(3',6'-dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-2',7'-diyl)bis(methanediylnitrilo)]tetraacetic acid
CAS	1461-15-0
EINECS	215-957-1
Chemical Formula	C30H26N2O13
Molecular Weight	622.53
inchi	InChI=1/C30H26N2O13/c33-21-7-23-19(5-15(21)9-31(11-25(35)36)12-26(37)38)30(18-4-2-1-3-17(18)29(43)45-30)20-6-16(22(34)8-24(20)44-23)10-32(13-27(39)40)14-28(41)42/h1-8,33-34H,9-14H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)
Package	100 mg
Price	Email to quote
Descriptions	Calcein Calcein MedChemExpress (MCE) HY-D0040 1461-15-0 Fluorexon RT, stored under nitrogen In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Calcein Calcein MedChemExpress (MCE) HY-D0040 1461-15-0 Fluorexon RT, stored under nitrogen In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Calcein is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium. Calcein can also be used as a model drug for evaluating efficiency and bioavailability of drug delivery systems. Calcein accumulates intracellularly in coelomocytes incubated in coelomic fluid or ISO-EDTA. Coelomocytes incubated in CF show an increase in the calcein fluorescence intensity compared to the control. Coelomocytes suspensions (ISO and CF) are separately incubated with calcein-AM (excitation and emission wavelength: 496 nm and 516 nm, respectively) at a final concentration of 200 nM, during 30 min, at 26°C. Calcein-AM is a nonfluorescent ABC transporter substrate whose intracellular accumulation is inversely proportional to ABC transporter activity. Intracellular esterases convert calcein-AM into the fluorescent dye calcein, which is not an ABC transporter substrate, thereby accumulating the dye inside the cell. Therefore, a high fluorescence signal indicates low ABC transporter activity whereas a low fluorescence signal indicates high activity. The fluorescence of samples is measured by flow cytometer. The experiment is repeated six times in duplicates. 515 489 \| \| \| \| \| \| \| \| \| \| [1]. Marques-Santos LF, et al. ABCB1 and ABCC1-like transporters in immune system cells from sea urchins Echinometra lucunter and Echinus esculentus and oysters Crassostrea gasar and Crassostrea gigas. Fish Shellfish Immunol. 2017 Sep 5 70:195-203. [Content Brief] [2]. Maherani B, et al., Calcein release behavior from liposomal bilayer influence of physicochemical/mechanical/structural properties of lipids. Biochimie. 2013 Nov 95(11):2018-33. [Content Brief]
Last Update	2025-04-01 14:45:47

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