Raspberry ketone MedChemExpress (MCE)

Product Name	4-(4-hydroxyphenyl)-2-butanone
Synonyms	RASBERRY KETONE Raspberry keton Raspberry Ketone RASPBERRY KETONE 4-Hydroxybenzylacetone Dobutamine EP Impurity B Raspberry ketone natural Synonyms RASBERRY KETONE Raspberry keton Raspberry Ketone RASPBERRY KETONE 4-Hydroxybenzylacetone Dobutamine EP Impurity B Raspberry ketone natural Raspberry ketone synthetic 4-p-Hydroxylphenyl)-2-butone Natural Raspberry Ketone 4-(4-hydroxyphenyl)butan-2-one 4-(4-hydroxyphenyl)-2-butanone 2-(4-Hydroxyphenyl)ethyl methyl ketone 4-(4-Hydroxyphenyl)-2-butanone 5471-51-2
CAS	5471-51-2
EINECS	226-806-4
Chemical Formula	C10H12O2
Molecular Weight	164.2
inchi	InChI=1/C10H12O2/c1-8(11)2-3-9-4-6-10(12)7-5-9/h4-7,12H,2-3H2,1H3
Package	10 mM * 1 mL;100 mg
Price	Email to quote
Descriptions	Raspberry ketone Raspberry ketone MedChemExpress (MCE) HY-N1426 5471-51-2 Frambione Descriptions Raspberry ketone Raspberry ketone MedChemExpress (MCE) HY-N1426 5471-51-2 Frambione 4-(4-Hydroxyphenyl)-2-butanone 99.73% 4°C, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (stored under nitrogen) Room temperature in continental US may vary elsewhere. Raspberry ketone is a major aromatic compound of red raspberry, widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff also shows PPAR-α agonistic activity. Raspberry ketone (1, 10, 20, and 50?μM) suppresses adipogenesis and lipid accumulation in 3T3-L1 pre-adipocytes. Raspberry ketone (10?μM) significantly blocks C/EBPα, PPARγ, and aP2 expression and increases the expression of ATGL and HSL, and CPT1B[1]. Raspberry ketone (0.5%, 1%, or 2%) increasses the levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol contents (LDL-C), ISI (insulin-sensitivr index), PPAR-α and LDLR, decreases the serum levels of AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), IRI (insulin resistance index), GLU (glucose), INS (insulin-sensitivr index), LEP (leptin), and TNF-α in rats compared with a high-fat diet-induced NASH model. Raspberry ketone also causes increased SOD activities[2]. Raspberry ketone shows cardioprotective action against isoproterenol-induced myocardial infarction in rats, and the effects may be due to its PPAR-α agonistic activity[3]. During the experimental period, the animal room holds four rats per cage, with free access to water and food, under conditions of temperature controlled at 20-26°C, humidity at 40-70%, and a 12/12-h day-night light cycle. Rats are fed with normal diet for 1 week and then randomly divided into five groups: normal control (NC) group (n=8) fed normal diet for 8 weeks, the model control (MC) group (n=8) fed high-fat diet (82% standard diet, 8.3% yolk powder, 9.0% lard, 0.5% cholesterol, and 0.2% sodium taurocholate), the Raspberry ketone low-dose (RKL) group (n=8), the Raspberry ketone middle-dose (RKM) group (n=8), and the Raspberry ketone high-dose (RKH) group (n=8). Rats are first fed with high-fat diet for 4 weeks, and then these rats are given intragastrically 0.5%, 1%, or 2% Raspberry ketone. The first two groups of rats are intragastrically administered salad oil at the same dose (2 mL/day per rat) once a day at 10:00 a.m., lasting for 4 weeks[2]. For the cytotoxicity study, 3T3-L1 pre-adipocytes are cultured and differentiated. After Raspberry ketone treatment for 4 d in DMEM containing 10% fetal bovine serum, the lactate dehydrogenase (LDH) concentration in the medium is immediately detected with the CytoTox 96 nonradioactive cytotoxicity assay kit[1]. PPAR-α \| \| \| \| \| \| \| \| \| \| [1]. Park KS. Raspberry ketone, a naturally occurring phenolic compound, inhibits adipogenic and lipogenic gene expression in 3T3-L1 adipocytes. Pharm Biol. 2015 Jun 53(6):870-5. [Content Brief]* [2]. Wang L, et al. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food. 2012 May 15(5):495-503. [Content Brief] [3]. Khan V, et al. Raspberry ketone protects against isoproterenol-induced myocardial infarction in rats. Life Sci. 2018 Feb 1 194:205-212. [Content Brief]
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Last Update	2025-04-01 14:45:47

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