Aclacinomycin A MedChemExpress (MCE)

Product Name	Aclarubicin
Synonyms	aclacur Jaclacin Aclarubicin ACLARUBLCIN ACLARUNBICIN antibiotic3082a aclarubicinfreebase Synonyms aclacur Jaclacin Aclarubicin ACLARUBLCIN ACLARUNBICIN antibiotic3082a aclarubicinfreebase 1-naphthacenecarboxylicacid,2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, [1R-(1α,2β,4β)]-
CAS	57576-44-0
EINECS	260-824-3
Chemical Formula	C42H53NO15
Molecular Weight	811.88
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Aclacinomycin A Aclacinomycin A MedChemExpress (MCE) HY-N2306 57576-44-0 Aclarubicin 98.94% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Aclacinomycin A Aclacinomycin A MedChemExpress (MCE) HY-N2306 57576-44-0 Aclarubicin 98.94% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis. Aclacinomycin A (0-120 μM, 30 min) inhibits the ubiquitin-ATP-dependent proteolytic activity of rabbit reticulocytes in a dose-dependent manner, with an IC50 of 52 μM. But it does not inhibit the ubiquitination[1]. Aclacinomycin A inhibits ubiquitin-ATP-dependent proteolysis after the conjugation of ubiquitin to proteins[1]. Aclacinomycin A (0-2.4 μM, 3 h) inhibits the topo II catalytic activity[2]. Aclacinomycin A (0-1.8 μM, 3 h) has negative effect on the proliferative rate of V79 and irs-2 cells[2]. Aclacinomycin A emits fluorescence and that human-cervical cancer HeLa cells exposed to Aclacinomycin A exhibits bright fluorescence signals in the cytoplasm when fluorescence microscopy was performed using the red filter (excitation 530-550 nm/emission 575 nm)[3]. Aclacinomycin A (0.75-6 mg/kg, IP, daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model[4]. Aclacinomycin A (0.6-20 mg/kg, Orally, daily) exhibits an antitumor effect on leukemia L-1210[4]. Aclacinomycin A is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD50 (76.5 mg/kg) is about twice the iv LD50 (35.6 mg/kg) in mice[4]. Topoisomerase I Topoisomerase II \| \| \| \| \| \| \| \| \| \| [1]. Isoe T, et al. Inhibition of different steps of the ubiquitin system by CDDP and aclarubicin. Biochim Biophys Acta. 1992 Sep 15 1117(2):131-5. [Content Brief] [2]. Hajji N, et al. Induction of genotoxic and cytotoxic damage by aclarubicin, a dual topoisomerase inhibitor. Mutat Res. 2005 May 2 583(1):26-35. [Content Brief] [3]. Iihoshi H, et al. Aclarubicin, an anthracycline anti-cancer drug, fluorescently contrasts mitochondria and reduces the oxygen consumption rate in living human cells. Toxicol Lett. 2017 Aug 5 277:109-114. [Content Brief] [4]. Hori S, Shirai M, Hirano S, Oki T, Inui T, Tsukagoshi S, Ishizuka M, Takeuchi T, Umezawa H. Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity. Gan. 1977 Oct 68(5):685-90. [Content Brief]
Supplier Website	https://www.medchemexpress.com/aclacinomycin-a.html
Last Update	2025-05-21 16:50:25

MedChemExpress (MCE) also provides

DAPI dilactate

Category: Fluorescent Dye
CAS: 28718-91-4
Last Update: 2025-05-21 16:50:25

Dibenzylfluorescein

Category: Fluorescent Dye
CAS: 97744-44-0
Last Update: 2025-05-21 16:50:25

DRAQ5

Category: Fluorescent Dye
CAS: 254098-36-7
Last Update: 2025-05-21 16:50:25

EDTA-AM

Category: Fluorescent Dye
CAS: 162303-59-5
Last Update: 2025-05-21 16:50:25

Rhodamine B hydrazide

Category: Fluorescent Dye
CAS: 74317-53-6
Last Update: 2025-05-21 16:50:25

NBD-Pen

Category: Fluorescent Dye
CAS: 1955505-54-0
Last Update: 2025-05-21 16:50:25

Citrazinic acid

Category: Fluorescent Dye
CAS: 99-11-6
Last Update: 2025-05-21 16:50:25

CY3-SE

Category: Fluorescent Dye
CAS: 146368-16-3
Last Update: 2025-05-21 16:50:25


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact