Direct Blue 1 MedChemExpress (MCE)

Product Name	Chicago Sky Blue 6B
Synonyms	C.I. 24410 Direct Blue 1 C.I. Direct Blue 1 Chicago Sky Blue?B PontamineSkyBlueBX Chicago Sky Blue 6B Direct Lake Blue 6B Synonyms C.I. 24410 Direct Blue 1 C.I. Direct Blue 1 Chicago Sky Blue?B PontamineSkyBlueBX Chicago Sky Blue 6B Direct Lake Blue 6B Pontamine Sky Blue 6BX chicago sky blue 6B (C.I. 24410) C.I. Direct Blue 1, tetrasodium salt 1,3-naphthalenedisulfonicacid,6,6'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl) 6,8-naphthalenedisulfonicacid,3,3'-((3,3'-dimethoxy-4,4'-biphenylene)bis(azo) tetrasodium 6,6'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxynaphthalene-1,3-disulphonate] 1,3-Naphthalenedisulfonic acid, 6,6-(3,3-dimethoxy1,1-biphenyl-4,4-diyl)bis(azo)bis4-amino-5-hydroxy-, tetrasodium salt tetrasodium (6Z,6'Z)-6,6'-[(3,3'-dimethoxybiphenyl-4,4'-diyl)di(1Z)hydrazin-2-yl-1-ylidene]bis(4-amino-5-oxo-5,6-dihydronaphthalene-1,3-disulfonate) tetrasodium (6Z)-4-amino-6-({4'-[(2E)-2-(8-amino-1-oxo-5,7-disulfonatonaphthalen-2(1H)-ylidene)hydrazino]-3,3'-dimethoxybiphenyl-4-yl}hydrazono)-5-oxo-5,6-dihydronaphthalene-1,3-disulfonate
CAS	2610-05-1
EINECS	220-026-8
Chemical Formula	C34H29N6NaO16S4
Molecular Weight	928.86
inchi	InChI=1/C34H28N6O16S4.4Na/c1-55-23-11-15(3-7-19(23)37-39-21-9-5-17-25(57(43,44)45)13-27(59(49,50)51)31(35)29(17)33(21)41)16-4-8-20(24(12-16)56-2)38-40-22-10-6-18-26(58(46,47)48)14-28(60(52,53)54)32(36)30(18)34(22)42 inchi InChI=1/C34H28N6O16S4.4Na/c1-55-23-11-15(3-7-19(23)37-39-21-9-5-17-25(57(43,44)45)13-27(59(49,50)51)31(35)29(17)33(21)41)16-4-8-20(24(12-16)56-2)38-40-22-10-6-18-26(58(46,47)48)14-28(60(52,53)54)32(36)30(18)34(22)42 /h3-14,37-38H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54) /q 4*+1/p-4/b39-21-,40-22-
Package	10 mM * 1 mL;500 mg
Price	Email to quote
Descriptions	Direct Blue 1 Direct Blue 1 MedChemExpress (MCE) HY-D0939 2610-05-1 Chicago Sky Blue 6B 95.0% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months Descriptions Direct Blue 1 Direct Blue 1 MedChemExpress (MCE) HY-D0939 2610-05-1 Chicago Sky Blue 6B 95.0% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Direct Blue 1 (Chicago Sky Blue 6B) is a complex dye for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1 is a potent and competitive VGLUT inhibitor. Direct Blue 1 can inhibit the Aβ-binding small molecule PrP ligand. Direct Blue 1 has anti-inflammatory activity. Direct Blue 1 (0.1, 1, 10 μM, 9 days) can bind α-synuclein and inhibit its aggregation, thus blocking the proliferation of α-synuclein between SH-SY5Y cells[4]. Direct Blue 1 (5, 10, 20 μM, 48 h) inhibits RANKL-induced osteoclasts and bone resorption in vitro by inhibiting NF-κB signaling and promoting proteasome-mediated MIF degradation[5]. Direct Blue 1 (2 or 8 mg/kg, subcutaneously, for 4 weeks) alleviates inflammatory bone destruction and osteoporosis induced by titanium particles in mice[5]. Direct Blue 1 (7.5 μg, intraventricular injection) alleviates methamphetamine-induced hyperactivity and behavioral sensitization in mice[6]. \| \| \| \| \| \| \| \| \| \| [1]. Lodha N, Poojary SA. A Novel Contrast Stain for the Rapid Diagnosis of Pityriasis Versicolor: A Comparison of Chicago Sky Blue 6B Stain, Potassium Hydroxide Mount and Culture. Indian J Dermatol. 2015 60(4):340-344. [Content Brief] [2]. Yu G, et al. The antinociceptive effects of intracerebroventricular administration of Chicago sky blue 6B, a vesicular glutamate transporter inhibitor. Behav Pharmacol. 2013 24(8):653-658. [Content Brief] [3]. Risse E, et al. Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay. J Biol Chem. 2015 290(27):17020-17028. [Content Brief] [4]. Min JO, et al. Chicago sky blue 6B inhibits α-synuclein aggregation and propagation. Mol Brain. 2022 Mar 28 15(1):27. [Content Brief] [5]. Jin K, et al. Chicago sky blue 6B (CSB6B), an allosteric inhibitor of macrophage migration inhibitory factor (MIF), suppresses osteoclastogenesis and promotes osteogenesis through the inhibition of the NF-κB signaling pathway. Biochem Pharmacol. 2021 Oct 192:114734. [Content Brief] [6]. He Z, et al. Chicago sky blue 6B, a vesicular glutamate transporters inhibitor, attenuates methamphetamine-induced hyperactivity and behavioral sensitization in mice. Behav Brain Res. 2013 Feb 15 239:172-6. [Content Brief]
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