Dehydrocrenatidine MedChemExpress (MCE)

Product Name	Dehydrocrenatidine
Synonyms	TOP3;TOP 3;TOP-3;Dehydrocrenatidine;O-Methylpicrasidine I;1-ethenyl-4,8-dimethoxy-9H-pyrido[3,4-b]indole;9H-Pyrido[3,4-b]indole, 1-ethenyl-4,8-dimethoxy-
CAS	65236-62-6
EINECS
Chemical Formula	C15H14N2O2
Molecular Weight	254.28
inchi
Package	1 mg
Price	Email to quote
Descriptions	Dehydrocrenatidine Dehydrocrenatidine MedChemExpress (MCE) HY-N3710 65236-62-6 Kumujian G Descriptions Dehydrocrenatidine Dehydrocrenatidine MedChemExpress (MCE) HY-N3710 65236-62-6 Kumujian G O-Methylpicrasidine I 98.0% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain. Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations[1]. Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation[1]. DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2]. Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations[1]. Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation[1]. DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 µM and 4.87 µM, respectively[2]. \| \| \| \| \| \| \| \| \| \| [1]. Jing Zhang, et al. Dehydrocrenatidine is a novel janus kinase inhibitor. Mol Pharmacol. 2015 Apr 87(4):572-81. [Content Brief]* [2]. Fang Zhao, et al. Dehydrocrenatidine Inhibits Voltage-Gated Sodium Channels and Ameliorates Mechanic Allodia in a Rat Model of Neuropathic Pain. Toxins (Basel). 2019 Apr 18 11(4):229. [Content Brief]
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