NADPH tetrasodium salt MedChemExpress (MCE)

Product Name	Dihydronicotinamide-adenine dinucleotide phosphate, tetrasodium salt
Synonyms	BETA-NADPH Beta-Nadph Tetrasodium Salt TRIPHOSPHOPYRIDINE NUCLEOTIDE, REDUCED FORM, TETRASODIUM BETA-TRIPHOSPHOPYRIDINE NUCLEOTIDE, SODIUM, REDUCED FORM TRIPHOSPYRIDINE NUCLEOTIDE, REDUCED FORM TETRASODIUM SALT Synonyms BETA-NADPH Beta-Nadph Tetrasodium Salt TRIPHOSPHOPYRIDINE NUCLEOTIDE, REDUCED FORM, TETRASODIUM BETA-TRIPHOSPHOPYRIDINE NUCLEOTIDE, SODIUM, REDUCED FORM TRIPHOSPYRIDINE NUCLEOTIDE, REDUCED FORM TETRASODIUM SALT TRIPHOSPHOPYRIDINE NUCLEOTIDE, REDUCED FORM TETRASODIUM SALT dihydronicotinamide-adenine dinucleotide phosphate tetrasodium BETA-TRIPHOSPHOPYRIDINE NUCLEOTIDE TETRASODIUM SALT,REDUCED FORM Dihydronicotinamide Adenine Dinucleotide Pphosphate Tetrasodium Salt Dihydronicotinamide-adenine dinucleotide phosphate, tetrasodium salt [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-tetrahydrofuran-2-yl]methyl [[(2R,3S,4R,5R)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] hydrogen phosphate tetrasodium [(2R,3S,4R,5R)-2-(6-aminopurin-9-yl)-5-[[[[(2R,3R,4S,5S)-5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxymethyl]-4-hydroxy-tetrahydrofuran-3-yl] phosphate
CAS	2646-71-1
EINECS	220-163-3
Chemical Formula	C21H31N7NaO17P3
Molecular Weight	769.42
inchi	InChI=1/C21H30N7O17P3.4Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32 /h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35) inchi InChI=1/C21H30N7O17P3.4Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32 /h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35) /q 4*+1/p-4/t10-,11-,13+,14-,15+,16+,20+,21- /m1..../s1
Package	25 mg;50 mg;100 mg
Price	Get quote
Descriptions	NADPH tetrasodium salt NADPH tetrasodium salt MedChemExpress (MCE) HY-F0003 2646-71-1 99.99% -20°C, stored under nitrogen, away from moisture The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US Descriptions NADPH tetrasodium salt NADPH tetrasodium salt MedChemExpress (MCE) HY-F0003 2646-71-1 99.99% -20°C, stored under nitrogen, away from moisture The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US may vary elsewhere. NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication. The demand for NADPH tetrasodium salt is particularly high in proliferating cancer cells, where it acts as a cofactor for the synthesis of nucleotides, proteins, and fatty acids. NADPH tetrasodium salt is also essential for the neutralization of the dangerously high levels of reactive oxygen species (ROS) generated by increased metabolic activity. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis. NADPH tetrasodium salt de novo synthesis is catalyzed by NAD kinases (NADKs), which catalyze the phosphorylation of NAD+ to form NADP+. NADPH tetrasodium salt is mainly involved in catabolic reactions, whereas NADPH tetrasodium salt is primarily involved in cellular antioxidative effects and anabolic reactions. NADPH tetrasodium salt is used by glutathione reductase (GR) to reduce oxidized glutathione (GSSG) to GSH[1]. The regeneration rate of NADPH tetrasodium salt is often the rate-limiting step for the over-production of desired chemicals, while maintaining robust cellular growth[2]. NADPH tetrasodium salt homeostasis is regulated by varied signaling pathways and several metabolic enzymes that undergo adaptive alteration in cancer cells. The metabolic reprogramming of NADPH tetrasodium salt renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative stress[3]. NADPH tetrasodium salt is an essential intracellular reductant needed to eliminate lipid hydroperoxides. Indeed, NADPH tetrasodium salt levels are a biomarker of ferroptosis sensitivity across many cancer cell lines[4]. Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Tedeschi PM, et al. NAD+ Kinase as a Therapeutic Target in Cancer. Clin Cancer Res. 2016 22(21):5189-5195. [Content Brief] [2]. Ng CY, F et al. Rational design of a synthetic Entner-Doudoroff pathway for improved and controllable NADPH regeneration. Metab Eng. 2015 29:86-96. [Content Brief] [3]. Ju HQ, Lin JF, et al. NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications. Signal Transduct Target Ther. 2020 5(1):231. Published 2020 Oct 7. [Content Brief] [4]. Stockwell BR, et al. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 2017 171(2):273-285. [Content Brief]
Last Update	2025-04-01 14:45:47

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