103285-22-9
5'-O-(4,4'-DIMETHOXYTRITYL)-2'-O-METHYLURIDINE
CAS: 103285-22-9
Molecular Formula: C31H32N2O8
103285-22-9 - Names and Identifiers
103285-22-9 - Physico-chemical Properties
| Molecular Formula | C31H32N2O8 |
| Molar Mass | 560.59 |
| Density | 1.35±0.1 g/cm3(Predicted) |
| Solubility | Soluble in acetonitrile |
| Appearance | Powder |
| Color | White to Pale Yellow |
| pKa | 9.39±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| MDL | MFCD00274123 |
| Physical and Chemical Properties | Storage Conditions: Store dry at 2-8 ℃ |
103285-22-9 - Introduction
DMT protective -2 '-methoxyuridine is a commonly used nucleoside protecting group. Its chemical name is 2 '-methoxydiethoxymethyluridine (2'-Methoxyethoxymethyl uridine), often abbreviated as DMT-2 '-MeUr. The following is a description of the nature, use, preparation and safety information of DMT-2 '-MeUr:
Nature:
-Appearance: White or off-white crystalline solid.
-Relative molecular mass: about 416.4g/mol.
-Solubility: DMT-2 '-MeUr dissolves well in some organic solvents, such as dimethyl sulfoxide (DMSO), methanol and dichloromethane.
Use:
-Prevent uncontrolled reactions of uridine in chemical synthesis.
-During the synthesis of nucleosides, DMT-2 '-MeUr is used as a protecting group, which can be easily removed after the reaction.
-plays the role of protecting bases in the synthesis of nucleic acid drugs such as RNA and DNA.
Preparation Method:
The method of preparing DMT-2 '-MeUr is more complicated and generally requires the technology of organic synthetic chemistry. The general synthetic route involves the reaction of 2 '-methoxydiethoxymethyluracil (2'-Methoxyethoxymethyl uracil) with galactose to give the DMT-2 '-MeUr product after appropriate workup and purification.
Safety Information:
- DMT-2 the safety of '-MeUr is generally good, but appropriate laboratory safety measures and personal protective measures are still needed.
-Irritating to eyes and skin, avoid contact with eyes and skin.
-When using, please operate correctly to avoid inhaling dust or solution.
-The DMT-2 '-MeUr should be stored in a dry, cool place, away from fire and oxidizing agents.
-For children and pets, DMT-2 '-MeUr should be placed in a place that is not easy to reach and avoid eating by mistake.
It should be noted that the above information is for reference only, and the specific safety operation must follow the relevant laboratory regulations and known safety data. If you need to use the DMT-2 '-MeUr, please consult a professional or a researcher in the relevant field for accurate operating instructions and safety information.
Nature:
-Appearance: White or off-white crystalline solid.
-Relative molecular mass: about 416.4g/mol.
-Solubility: DMT-2 '-MeUr dissolves well in some organic solvents, such as dimethyl sulfoxide (DMSO), methanol and dichloromethane.
Use:
-Prevent uncontrolled reactions of uridine in chemical synthesis.
-During the synthesis of nucleosides, DMT-2 '-MeUr is used as a protecting group, which can be easily removed after the reaction.
-plays the role of protecting bases in the synthesis of nucleic acid drugs such as RNA and DNA.
Preparation Method:
The method of preparing DMT-2 '-MeUr is more complicated and generally requires the technology of organic synthetic chemistry. The general synthetic route involves the reaction of 2 '-methoxydiethoxymethyluracil (2'-Methoxyethoxymethyl uracil) with galactose to give the DMT-2 '-MeUr product after appropriate workup and purification.
Safety Information:
- DMT-2 the safety of '-MeUr is generally good, but appropriate laboratory safety measures and personal protective measures are still needed.
-Irritating to eyes and skin, avoid contact with eyes and skin.
-When using, please operate correctly to avoid inhaling dust or solution.
-The DMT-2 '-MeUr should be stored in a dry, cool place, away from fire and oxidizing agents.
-For children and pets, DMT-2 '-MeUr should be placed in a place that is not easy to reach and avoid eating by mistake.
It should be noted that the above information is for reference only, and the specific safety operation must follow the relevant laboratory regulations and known safety data. If you need to use the DMT-2 '-MeUr, please consult a professional or a researcher in the relevant field for accurate operating instructions and safety information.
Last Update：2024-04-09 19:05:44
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