107582-20-7
Methyl 2,3-diaminobenzoate
CAS: 107582-20-7
Molecular Formula: C8H10N2O2
107582-20-7 - Names and Identifiers
| Name | Methyl 2,3-diaminobenzoate |
| Synonyms | Methyl 2,3-diaminobenzoate METHYL 2,3-DIAMINOBENZOATE 2,3-DIAMINOBENZOIC ACID METHYL ESTER 2,3-diamino benzoicacid methyl ester 2,3-Diaminobenzoic acid methyl ester 2,3-Diamino-benzoic acid methyl ester Benzoic acid, 2,3-diamino-, methyl ester 2,3-Diaminobenzoic Acid Methyl EsterDiscontinued. See D416211 |
| CAS | 107582-20-7 |
| InChI | InChI=1/C8H10N2O2/c1-12-8(11)5-3-2-4-6(9)7(5)10/h2-4H,9-10H2,1H3 |
107582-20-7 - Physico-chemical Properties
| Molecular Formula | C8H10N2O2 |
| Molar Mass | 166.18 |
| Density | 1.260±0.06 g/cm3(Predicted) |
| Melting Point | 68-70°C |
| Boling Point | 322.6±22.0 °C(Predicted) |
| Flash Point | 176.5°C |
| Vapor Presure | 0.000277mmHg at 25°C |
| Appearance | Yellow solid |
| Color | Light yellow to Brown |
| pKa | 3.02±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Refractive Index | 1.622 |
107582-20-7 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36/37 - Wear suitable protective clothing and gloves. |
107582-20-7 - Reference Information
| Application | Methyl 2,3-diaminobenzoate is a pharmaceutical intermediate that can be used to prepare 2-ethoxy-4-methyl formate-3-hydro-benzimidazole, and then trityl candesartan intermediate can be prepared. |
| preparation | step 1. the preparation of 2-methyl formate -6-nitro-benzoic acid 200 g3-nitrophthalic acid and 1L methanol are added to the reaction bottle. 104mL of thionyl chloride was added dropwise in ice water bath, and the dripping was completed in 2 hours. Heat up to reflux and react for 24 hours. The reaction mixture was concentrated to dry and washed with petroleum ether. Filtration resulted in 210.5g of 2-methyl formate -6-nitro-benzoic acid white solid with a yield of 99%. Step 2. the preparation of 2-amino -3-nitro-benzoate methyl 100 2-methyl formate -6-nitro-benzoic acid, 800mL chloroform and 133.3mL 98% sulfuric acid were sequentially added to the reaction bottle. 56g of sodium azide was added in batches at room temperature for about 100min. The temperature was raised to 50 ℃ and the reaction was carried out for 22 hours. The reaction mixture is cooled to room temperature, the solvent is decanted, the chloroform is washed, 400mL of water is added, and filtered to obtain 78.4g of yellow solid with a yield of 90%. Step 3. Preparation of methyl 2,3-diaminobenzoate Methyl 5g2-amino-3-nitro-benzoate, 50mL concentrated hydrochloric acid, 25 gSnCl2 · 2H2O were sequentially added to the reaction bottle and reacted at room temperature for 5 hours. The reaction mixture was adjusted to pH to 8 with saturated sodium carbonate solution, ethyl acetate extraction, organic phases were combined, and solvent was distilled to obtain 4g of light yellow solid of 2, 3-diamino-benzoate. |
Last Update：2024-04-09 02:00:05
Supplier List
Featured ProductsSpot supply
Product Name: Methyl 2,3-diaminobenzoate Visit Supplier Webpage Request for quotationCAS: 107582-20-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Methyl 2,3-diaminobenzoate Request for quotationCAS: 107582-20-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Methyl 2,3-diaminobenzoate Visit Supplier Webpage Request for quotationCAS: 107582-20-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 23-Diamino-benzoic acid methyl ester Visit Supplier Webpage Request for quotationCAS: 107582-20-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: Methyl 2,3-diaminobenzoate Request for quotation
CAS: 107582-20-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 107582-20-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: Methyl 2,3-diaminobenzoate Visit Supplier Webpage Request for quotation
CAS: 107582-20-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 107582-20-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Methyl 2,3-diaminobenzoate Visit Supplier Webpage Request for quotationCAS: 107582-20-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Methyl 2,3-diaminobenzoate Request for quotationCAS: 107582-20-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Methyl 2,3-diaminobenzoate Visit Supplier Webpage Request for quotationCAS: 107582-20-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 23-Diamino-benzoic acid methyl ester Visit Supplier Webpage Request for quotationCAS: 107582-20-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: Methyl 2,3-diaminobenzoate Request for quotation
CAS: 107582-20-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 107582-20-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: Methyl 2,3-diaminobenzoate Visit Supplier Webpage Request for quotation
CAS: 107582-20-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 107582-20-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History