107761-42-2
beta-Amyloid (1-42) human
CAS: 107761-42-2
Molecular Formula: C199H307N53O59S
107761-42-2 - Names and Identifiers
| Name | beta-Amyloid (1-42) human |
| Synonyms | (1-42) (human) beta-Amyloid (1-42) human AB42, betaamyloid peptide Β-AMYLOID PEPTIDE (1-42), RAT Amyloid β Protein Fragment 1-42 Beta-Amyloid (1-42), sodium salt |
| CAS | 107761-42-2 |
| InChIKey | XPESWQNHKICWDY-QYFPAAMGSA-N |
107761-42-2 - Physico-chemical Properties
| Molecular Formula | C199H307N53O59S |
| Molar Mass | 4417.95 |
| Solubility | Soluble in ammonium hydroxide, pH >9. Also soluble in DMSO. |
| Appearance | Lyophilized |
| Storage Condition | -20°C |
| Physical and Chemical Properties | Character soybean peptide is white to yellowish powder. Soybean peptide has good processing properties such as no beanty smell, no protein denaturation, acid and no precipitation, heating and no solidification, easily soluble in water, and good fluidity. It is an excellent health food material. |
| Use | Efficacy and role Soybean peptide has the function of quickly recovering fatigue and enhancing muscle strength; it has the function of lowering cholesterol; it has the function of treating various amino acid absorption deficit; it has the effect of promoting energy metabolism and weight loss; it has the effect of lowering blood sugar; lowering blood pressure and blood lipids; other effects: it has the effect of anti-oxidation and regulating insulin function. |
107761-42-2 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29332900 |
107761-42-2 - Uses and synthesis methods
Introduction
soybean peptide is a polypeptide mixture obtained by hydrolysis or separation and refining of soybean protein by acid method or enzymatic method. it is mainly composed of small molecule peptides, and also contains a small amount of macromolecular peptides, free amino acids, sugars and inorganic salts, with molecular mass below 5000u. The protein content of soybean peptide is about 85%, and its amino acid composition is the same as that of soybean protein. It must be well balanced and rich in amino acids.
biological activity
β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a peptide composed of 42 amino acids, which plays a key role in the pathogenesis of Alzheimer's disease.
in vitro studies
β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure.
2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃.
3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing.
4. Next, the solution was age 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments.
Methods vary depends on the downstream applications.
Last Update：2024-04-09 21:01:54
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