116-43-8
Succinylsulfathiazole
CAS: 116-43-8
Molecular Formula: C13H13N3O5S2
116-43-8 - Names and Identifiers
| Name | Succinylsulfathiazole |
| Synonyms | SST kaoxidin KAOXIDINE colistatin sulfasuccinil sulfasuccidin cremosuxidine sulfasuccidine sulfasuccithiazole Succinylsulfathiazole 4-oxo-4-{[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]amino}butanoic acid |
| CAS | 116-43-8 |
| EINECS | 204-141-0 |
| InChI | InChI=1/C13H13N3O5S2/c17-11(5-6-12(18)19)15-9-1-3-10(4-2-9)23(20,21)16-13-14-7-8-22-13/h1-4,7-8H,5-6H2,(H,14,16)(H,15,17)(H,18,19) |
116-43-8 - Physico-chemical Properties
| Molecular Formula | C13H13N3O5S2 |
| Molar Mass | 355.39 |
| Density | 1.4807 (rough estimate) |
| Melting Point | 193.5°C |
| Water Solubility | 0.49g/L(38 ºC) |
| Solubility | 1 M NaOH: soluble50mg/mL |
| Appearance | White powder |
| Color | white to off-white |
| Maximum wavelength(λmax) | ['282nm(H2O (pH 3.3 - 5))(lit.)'] |
| Merck | 14,8877 |
| BRN | 349989 |
| pKa | pKa 4.5 (Uncertain) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.6390 (estimate) |
| MDL | MFCD00022437 |
116-43-8 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | WM4767000 |
| HS Code | 29350090 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
116-43-8 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | succinyl sulfathiazole is a sulfonamide antibiotic that can inhibit bacteria that cause folic acid production. Succinylsulfamethiazole is used in the study of various folate deficiencies to prevent the synthesis of folate. |
| preparation | the manufacture of succinyl sulfathiazole is usually obtained by condensation of succinic anhydride and sulfathiazole in a dry organic solvent, with a yield of about 92%. the choice of solvent is hydrophilic solvent. Succinyl sulfathiazole can also be synthesized by solid phase, and the starting material is still succinic anhydride and sulfathiazole. Solid phase synthesis is much better than solvent condensation. The advantages are as follows: 1. No organic solvent is required; 2. Simple equipment and easy operation; 3. Safety; 4. High yield and low cost; 5. The difference between the starting material succinic anhydride and sulfathiazole is small. The preparation reaction formula is as follows: fig. 1 succinyl sulfamethiazole preparation reaction formula |
| biological activity | Succinylsulfathiazole (Succinylsulphathiazole) is a sulfonamide antibiotic. |
Last Update：2024-04-09 20:52:54
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