1184136-10-4
UNC-926 Hydrochloride
CAS: 1184136-10-4
Molecular Formula: C16H21BrN2O
1184136-10-4 - Names and Identifiers
1184136-10-4 - Physico-chemical Properties
| Molecular Formula | C16H21BrN2O |
| Molar Mass | 337.25 |
| Solubility | DMSO: soluble2mg/mL, clear (warmed) |
| Appearance | powder |
| Color | white to light brown |
| Storage Condition | 2-8°C |
| In vitro study | UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC 50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7. UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1. |
1184136-10-4 - Risk and Safety
| WGK Germany | 3 |
1184136-10-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.676 ml | 13.379 ml | 26.758 ml |
| 5 mM | 0.535 ml | 2.676 ml | 5.352 ml |
| 10 mM | 0.268 ml | 1.338 ml | 2.676 ml |
| 5 mM | 0.054 ml | 0.268 ml | 0.535 ml |
Last Update：2024-01-02 23:10:35
1184136-10-4 - Reference Information
| biological activity | UNC926 is a methyl-lysine (Kme) reader domain inhibitor, which can specifically inhibit L3MBTL1, and its IC50 is 3.9 μM. |
| target | TargetValue L3MBTL1 () 3.9 μM(Kd) |
| Target | Value |
| L3MBTL1 () | 3.9 μM(Kd) |
| in vitro study | UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC 50 of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7. UNC926 (1-25μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a pose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1. |
| use | UNC-926 is a methyl-lysine reader antagonist; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). UNC-926 selectively inhibits the interaction between L3MBTL13XMBT-H4K20me1 in a peptide pull down say. |
Last Update：2024-04-09 21:11:58
Supplier List
Featured ProductsSpot supply
Product Name: UNC-926 Visit Supplier Webpage Request for quotationCAS: 1184136-10-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: UNC926 Request for quotationCAS: 1184136-10-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: UNC926 Visit Supplier Webpage Request for quotationCAS: 1184136-10-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: UNC926 Visit Supplier Webpage Request for quotationCAS: 1184136-10-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: UNC-926 Hydrochloride Visit Supplier Webpage Request for quotationCAS: 1184136-10-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: UNC-926 Visit Supplier Webpage Request for quotationCAS: 1184136-10-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: UNC926 Request for quotationCAS: 1184136-10-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: UNC926 Visit Supplier Webpage Request for quotationCAS: 1184136-10-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: UNC926 Visit Supplier Webpage Request for quotationCAS: 1184136-10-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: UNC-926 Hydrochloride Visit Supplier Webpage Request for quotationCAS: 1184136-10-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
1184136-10-4
895240-50-3
506-50-3
887650-05-7
直接黄12
4-Bromo-2-nitrobenzonitrile
506-38-7
Thiol-PEG1-NH2
105391-65-9
13515-99-6
895240-50-3
506-50-3
887650-05-7
直接黄12
4-Bromo-2-nitrobenzonitrile
506-38-7
Thiol-PEG1-NH2
105391-65-9
13515-99-6