1185292-80-1

1185292-80-1 - Names and Identifiers

Name	ethyl 6-fluoro-2-(trifluoromethyl)quinoline-4-carboxylate
Synonyms	Ethyl 6-fluoro-2-(trifluoromethyl)quinoline-4-carboxylate ethyl 6-fluoro-2-(trifluoromethyl)quinoline-4-carboxylate 4-Quinolinecarboxylic acid, 6-fluoro-2-(trifluoromethyl)-, ethyl ester
CAS	1185292-80-1
InChI	InChI=1S/C13H9F4NO2/c1-2-20-12(19)9-6-11(13(15,16)17)18-10-4-3-7(14)5-8(9)10/h3-6H,2H2,1H3

1185292-80-1 - Physico-chemical Properties

Molecular Formula	C13H9F4NO2
Molar Mass	287.21
Density	1.374±0.06 g/cm3(Predicted)
Boling Point	321.5±42.0 °C(Predicted)
pKa	-2.57±0.50(Predicted)

1185292-80-1 - Risk and Safety

Risk Codes	20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S24/25 - Avoid contact with skin and eyes. S36/37 - Wear suitable protective clothing and gloves.
HS Code	29334900

1185292-80-1 - Introduction

6-Fluoro-2-trifluoromethylquinoline-4-carboxylic acid ethyl ester (Trifluoromethyl) is an organic compound whose chemical formula is C13H7F4NO2.

Nature:
Ethyl 6-fluoro-2-trifluoromethylquinoline -4-carboxylate is a colorless to light yellow liquid with good solubility and stability. It is a drug intermediate with strong fluorine compound properties.

Use:
Ethyl 6-fluoro-2-trifluoromethylquinoline -4-carboxylate is widely used in the field of organic synthesis. It can be used as an important heterocyclic reagent for the synthesis of a variety of drugs and pesticides. It can also be used in the preparation of field herbicides, insecticides, fungicides and anticancer drugs.

Preparation Method:
The synthesis of 6-fluoro-2-trifluoromethylquinoline -4-carboxylic acid ethyl ester can be achieved through various routes. A common method is to react 3,5-difluoro-2-iodoquinoline with trifluoromethyl ethyl ester, and carry out a substitution reaction under alkali catalysis to obtain the product.

Safety Information:
Ethyl 6-fluoro-2-trifluoromethylquinoline-4-carboxylate is relatively safe under normal operating conditions. However, it is necessary to take appropriate protective measures during use or storage to avoid contact with skin, eyes and respiratory system. Work in a well-ventilated area and wear appropriate protective equipment such as protective gloves, goggles and protective masks. If it comes into contact with skin or eyes, rinse immediately with plenty of water and seek medical attention. In addition, the compound should be stored in a cool, dry and well-ventilated place, away from fire and combustibles.

Last Update：2024-04-09 20:52:54