123639-61-2
Fmoc-L-glutamic acid 5-benzyl ester
CAS: 123639-61-2
Molecular Formula: C27H25NO6
123639-61-2 - Names and Identifiers
| Name | Fmoc-L-glutamic acid 5-benzyl ester |
| Synonyms | FMOC-GLU(OBZL) FMOC-Glu(OBzl) Fmoc-Glu(Bzl)-OH FMOC-GLU(OBZL)-OH Fmoc-Glu(OBzl)-OH FMOC-GLUTAMIC ACID(OBZL)-OH Fmoc-L-glutamic acid 5-benzyl ester FMOC-L-GLUTAMIC ACID 5-BENZYL ESTER Fmoc-L-glutamic acid-gamma-benzyl ester FMOC-L-GLUTAMIC ACID-GAMMA-BENZYL ESTER (9H-Fluoren-9-yl)MethOxy]Carbonyl Glu(OBzl)-OH N-ALPHA-FMOC-L-GLUTAMIC ACID GAMMA-BENZYL ESTER N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-GLUTAMIC ACID GAMMA-BENZYL ESTER (2S)-5-(benzyloxy)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-5-oxopentanoic acid (non-preferred name) |
| CAS | 123639-61-2 |
| InChI | InChI=1/C27H25NO6/c29-25(33-16-18-8-2-1-3-9-18)15-14-24(26(30)31)28-27(32)34-17-23-21-12-6-4-10-19(21)20-11-5-7-13-22(20)23/h1-13,23-24H,14-17H2,(H,28,32)(H,30,31)/t24-/m0/s1 |
123639-61-2 - Physico-chemical Properties
| Molecular Formula | C27H25NO6 |
| Molar Mass | 459.49 |
| Density | 1.289±0.06 g/cm3(Predicted) |
| Melting Point | Decomposes |
| Boling Point | 698.2±55.0 °C(Predicted) |
| Flash Point | 376.1°C |
| Vapor Presure | 1.83E-20mmHg at 25°C |
| Appearance | Powder |
| pKa | 3.70±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.613 |
| MDL | MFCD00065642 |
123639-61-2 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 2924 29 70 |
123639-61-2 - Introduction
Fluorenylmethoxycarbonyl-L-glutamic acid-Γ-benzyl ester (English abbreviation: Fmoc-L-Glu(OtBu)-OH) is an organic compound used in peptide synthesis in solid phase synthesis. Its nature includes the following aspects:
-Appearance: White to light yellow solid
-Molecular formula: C29H31NO8
-Molecular weight: 525.56g/mol
-melting point: 123-124 ℃
-Solubility: Fmoc-L-Glu(OtBu)-OH has good solubility in common organic solvents.
The main use of Fmoc-L-Glu(OtBu)-OH is as a protecting group in peptide synthesis. In the synthesis of the peptide chain, Fmoc-L-Glu(OtBu)-OH is bound to the amino acid, protecting its activity from non-specific reaction with other reactants. After completion of the reaction, Fmoc-L-Glu(OtBu)-OH can be removed by removing the protecting group to restore the activity of the amino acid.
The method of preparing Fmoc-L-Glu(OtBu)-OH is relatively complex and generally requires the use of a series of organic synthesis steps. First, glutamic acid is reacted with bromoacetate to obtain glutamic acid ethyl ester. The glutamic acid ethyl ester is then reacted with benzyl alcohol to form the glutamic acid ethyl ester benzyl alcohol ester. Finally, glutamic acid ethyl ester benzyl alcohol ester was reacted with Fmoc-Cl to produce the target product Fmoc-L-Glu(OtBu)-OH.
Regarding safety information, Fmoc-L-Glu(OtBu)-OH is a laboratory drug and needs to be used under safe laboratory operation. Follow general laboratory safety practices, including wearing personal protective equipment (e. g., lab gloves, goggles, etc.), avoiding skin contact and inhalation, and operating in a well-ventilated laboratory. At the same time, the compound should be stored in a sealed container, away from fire and oxidizing agents.
-Appearance: White to light yellow solid
-Molecular formula: C29H31NO8
-Molecular weight: 525.56g/mol
-melting point: 123-124 ℃
-Solubility: Fmoc-L-Glu(OtBu)-OH has good solubility in common organic solvents.
The main use of Fmoc-L-Glu(OtBu)-OH is as a protecting group in peptide synthesis. In the synthesis of the peptide chain, Fmoc-L-Glu(OtBu)-OH is bound to the amino acid, protecting its activity from non-specific reaction with other reactants. After completion of the reaction, Fmoc-L-Glu(OtBu)-OH can be removed by removing the protecting group to restore the activity of the amino acid.
The method of preparing Fmoc-L-Glu(OtBu)-OH is relatively complex and generally requires the use of a series of organic synthesis steps. First, glutamic acid is reacted with bromoacetate to obtain glutamic acid ethyl ester. The glutamic acid ethyl ester is then reacted with benzyl alcohol to form the glutamic acid ethyl ester benzyl alcohol ester. Finally, glutamic acid ethyl ester benzyl alcohol ester was reacted with Fmoc-Cl to produce the target product Fmoc-L-Glu(OtBu)-OH.
Regarding safety information, Fmoc-L-Glu(OtBu)-OH is a laboratory drug and needs to be used under safe laboratory operation. Follow general laboratory safety practices, including wearing personal protective equipment (e. g., lab gloves, goggles, etc.), avoiding skin contact and inhalation, and operating in a well-ventilated laboratory. At the same time, the compound should be stored in a sealed container, away from fire and oxidizing agents.
Last Update：2024-04-10 22:41:03
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