124750-99-8

124750-99-8 - Names and Identifiers

Name	Losartan Potassium
Synonyms	MK 954 Losartan Potassium LOSARTAN POTASSIUM LOSARTAN POTASSIUM SALT LOSARTAN MONOPOTASSIUM SALT 1h-imidazole-5-methanol,2-butyl-4-chloro-1-((2'-(1h-tetrazol-5-yl)(1,1'-biphe 2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL potassium (2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanolate potassium 5-(4'-{[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl}biphenyl-2-yl)tetrazol-1-ide 2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOLE-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL, POTASSIUM SALT 2-butyl-4-chloro-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-methanol monopotassium salt
CAS	124750-99-8
EINECS	200-287-4
InChI	InChI=1/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12H,2-3,8,13-14H2,1H3,(H,25,26,27,28);/q-1;+1
InChIKey	OXCMYAYHXIHQOA-UHFFFAOYSA-N

124750-99-8 - Physico-chemical Properties

Molecular Formula	C22H23ClKN6O
Molar Mass	462.01
Melting Point	263-265°C
Boling Point	682°C at 760 mmHg
Flash Point	366.3°C
Solubility	Soluble in water (>500 mg/ml), PBS (pH 7.2) (≥10 mg/ml), ethanol (≥20 mg/ml), DMSO (10
Vapor Presure	1.55E-19mmHg at 25°C
Appearance	White to yellowish powder
Color	Off-white
Merck	14,5583
BRN	5845770
Storage Condition	Inert atmosphere,Room Temperature
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
MDL	MFCD02092704
Use	A specific antagonist of the AT1 receptor with significant downstream effects.
In vivo study	In monkeys with diet-induced hypercholesterolemia, Losartan(180 mg/day) caused a significant increase in plasma angiotensin II and angiotensin-(1-7). In monkeys with diet-induced hypercholesterolemia, Losartan(180 mg/day) reduced approximately 50% of the extent of fatty striae in the aorta, coronary arteries, and carotid arteries. In monkeys with diet-induced hypercholesterolemia, Losartan reduced the susceptibility to in vitro oxidation of low-density lipoprotein, serum levels of monocyte chemoattractant protein -1, and expression of circulating monocyte CD11b. In pregnant fbn1-apolipoprotein E-deficient mice, Losartan(5 mg/kg/day) caused a significant decrease in the development of atherosclerotic lesions. In apolipoprotein E-deficient mice, Losartan(5 mg/kg/day) significantly reduced the sensitivity of mouse LDL to fat oxidation after incubation in the presence of cuso4. In male Sprague Dawley rats, Losartan (10 mg/kg) administration increased angiotensin levels 4-to 6-fold without altering blood BK levels. In male Sprague Dawley rats, Losartan (10 mg/kg) increased plasma renin levels 100-fold and plasma angiotensin levels were reduced to 24% of controls without altering plasma aldisterol levels.

124750-99-8 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany	3
RTECS	NI6755100
HS Code	2933290000

124750-99-8 - Nature

Open Data Verified Data

white or off-white flowable crystalline powder. Very soluble in water, soluble in methanol or ethanol, slightly soluble in acetonitrile, methyl ethyl ketone and other general organic solvents, almost insoluble in chloroform.

Last Update：2025-06-10 22:55:16

124750-99-8 - Preparation Method

Open Data Verified Data

2-butyl -4-chlorine 5-hydroxymethyl imidazole and sodium methoxide methanol solution stirring reaction, the formation of sodium salt and 4 '-bromomethyl-2-cyanobiphenyl in dimethylformamide, the obtained compound is etherified and then reacted with sodium azide in dimethylformamide containing ammonium chloride to obtain losartan by acidic hydrolysis.

Last Update：2025-06-10 22:55:16

124750-99-8 - Application

Open Data Verified Data

Cozaar was first launched in 1994 and is currently approved in 93 countries for the treatment of hypertension. Oral administration of non-peptide angiotensin II receptor antagonists. Mainly used for primary hypertension. Cozaar is the first angiotensin II receptor antagonist (AIIA) class of antihypertensive drugs.

Last Update：2025-08-19 16:24:40

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View History

124750-99-8
90131-19-4
15115-60-3
259860-01-0
1120-24-7
BIX 01204
Plumbic acid
548-89-0
Phenyl Butazone Sodium Salt
Succinoyl dichloride

124750-99-8

Losartan Potassium

CAS: 124750-99-8

Molecular Formula: C22H23ClKN6O

124750-99-8 - Names and Identifiers

124750-99-8 - Physico-chemical Properties

124750-99-8 - Risk and Safety

124750-99-8 - Nature

Open Data Verified Data

124750-99-8 - Preparation Method

Open Data Verified Data

124750-99-8 - Application

Open Data Verified Data

Supplier List

124750-99-8 Request for Quotation

Losartan Potassium

CAS: 124750-99-8

Molecular Formula: C22H23ClKN6O

124750-99-8 - Names and Identifiers

124750-99-8 - Physico-chemical Properties

124750-99-8 - Risk and Safety

124750-99-8 - Nature

Open Data Verified Data

124750-99-8 - Preparation Method

Open Data Verified Data

124750-99-8 - Application

Open Data Verified Data

Supplier List

124750-99-8