1297538-32-9
ODM-201
CAS: 1297538-32-9
Molecular Formula: C19H19ClN6O2
1297538-32-9 - Names and Identifiers
1297538-32-9 - Physico-chemical Properties
| Molecular Formula | C19H19ClN6O2 |
| Molar Mass | 398.8462 |
| Density | 1.41±0.1 g/cm3(Predicted) |
| Boling Point | 719.5±60.0 °C(Predicted) |
| Solubility | DMSO: ≥ 44 mg/mL |
| pKa | 11.10±0.10(Predicted) |
| Storage Condition | -20℃ |
| MDL | MFCD29472270 |
| Physical and Chemical Properties | Bioactive Darolutamide (ODM-201, BAY-1841788) is a new androgen receptor (AR) antagonist, which can block AR nuclear transport with Ki of f 11 nM. Phase 3. |
1297538-32-9 - Upstream Downstream Industry
1297538-32-9 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.507 ml | 12.536 ml | 25.072 ml |
| 5 mM | 0.501 ml | 2.507 ml | 5.014 ml |
| 10 mM | 0.251 ml | 1.254 ml | 2.507 ml |
| 5 mM | 0.05 ml | 0.251 ml | 0.501 ml |
Last Update：2024-01-02 23:10:35
1297538-32-9 - Uses and synthesis methods
target
Target Value
Androgen receptor 11 nM(Ki)
in vitro study
In AR-HEK293 cells that stably express full-length hAR, human AR (hAR) is ODM-201 inhibited, and the IC50 is 26 nM. ODM-201 inhibited VCaP cell proliferation, IC50 was 230 nM, but had no effect on the activity of the tested AR-negative cell lines, DU-145 prostate cancer cells and H1581 lung cancer cells.
in vivo studies
In mice loaded with VCaP xenografts, ODM-201 (50 mg/kg, p.o.) significantly inhibited the growth of castration-resistant prostate tumors.
Last Update：2024-04-09 21:21:28
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Product Name: ODM-201 Visit Supplier Webpage Request for quotationCAS: 1297538-32-9
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Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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Multiple SpecificationsSpot supply
Product Name: ODM-201; BAY-1841788 Visit Supplier Webpage Request for quotationCAS: 1297538-32-9
Tel: 609-228-6898
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Mobile: 609-228-6898
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Product Name: ODM-201 Visit Supplier Webpage Request for quotationCAS: 1297538-32-9
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View History
1297538-32-9
500-22-1
620113-73-7
1190-16-5
3-Azetidinyl 2-(2-methoxyethoxy)ethyl ether
Octen-3-ol
2-OCTYLENE
GSK-J1
6952-89-2
康布瑞汀
500-22-1
620113-73-7
1190-16-5
3-Azetidinyl 2-(2-methoxyethoxy)ethyl ether
Octen-3-ol
2-OCTYLENE
GSK-J1
6952-89-2
康布瑞汀
Raw Materials for 1297538-32-9
5-(1-Hydroxyethyl)-1H-pyrazole-3-carboxylic acid
2-chloro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzonitrile
ORM-15341
4-BROMO-2-CHLOROBENZONITRILE
2-chloro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzonitrile
ORM-15341
4-BROMO-2-CHLOROBENZONITRILE