ODM-201
ODM-201
CAS: 1297538-32-9
Molecular Formula: C19H19ClN6O2
ODM-201 - Names and Identifiers
ODM-201 - Physico-chemical Properties
| Molecular Formula | C19H19ClN6O2 |
| Molar Mass | 398.8462 |
| Density | 1.41±0.1 g/cm3(Predicted) |
| Boling Point | 719.5±60.0 °C(Predicted) |
| Solubility | DMSO: ≥ 44 mg/mL |
| pKa | 11.10±0.10(Predicted) |
| Storage Condition | -20℃ |
| MDL | MFCD29472270 |
| Physical and Chemical Properties | Bioactive Darolutamide (ODM-201, BAY-1841788) is a new androgen receptor (AR) antagonist, which can block AR nuclear transport with Ki of f 11 nM. Phase 3. |
ODM-201 - Upstream Downstream Industry
ODM-201 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.507 ml | 12.536 ml | 25.072 ml |
| 5 mM | 0.501 ml | 2.507 ml | 5.014 ml |
| 10 mM | 0.251 ml | 1.254 ml | 2.507 ml |
| 5 mM | 0.05 ml | 0.251 ml | 0.501 ml |
Last Update：2024-01-02 23:10:35
ODM-201 - Uses and synthesis methods
target
Target Value
Androgen receptor 11 nM(Ki)
in vitro study
In AR-HEK293 cells that stably express full-length hAR, human AR (hAR) is ODM-201 inhibited, and the IC50 is 26 nM. ODM-201 inhibited VCaP cell proliferation, IC50 was 230 nM, but had no effect on the activity of the tested AR-negative cell lines, DU-145 prostate cancer cells and H1581 lung cancer cells.
in vivo studies
In mice loaded with VCaP xenografts, ODM-201 (50 mg/kg, p.o.) significantly inhibited the growth of castration-resistant prostate tumors.
Last Update：2024-04-09 21:21:28
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Tel: +86-18821248368
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QQ: 495145328
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Multiple SpecificationsSpot supply
Product Name: ODM-201 Request for quotationCAS: 1297538-32-9
Tel: 400-968-2212
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Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
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Product Name: ODM-201 Visit Supplier Webpage Request for quotationCAS: 1297538-32-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
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Multiple SpecificationsSpot supply
Product Name: ODM-201; BAY-1841788 Visit Supplier Webpage Request for quotationCAS: 1297538-32-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: ODM-201 Visit Supplier Webpage Request for quotationCAS: 1297538-32-9
Tel: +16314854226
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View History
Raw Materials for ODM-201