13609-67-1
hydrocortisone 17-butyrate
CAS: 13609-67-1
Molecular Formula: C25H36O6
13609-67-1 - Names and Identifiers
| Name | hydrocortisone 17-butyrate |
| Synonyms | h.17b hb(sub17) CORTISOL 17-BUTYRATE HYDROCORTISONE BUTYRATE Hydrocortisone Butyrate Hydrocortisone-17-butyrate HYDROCORTISONE 17-BUTYRATE hydrocortisone 17-butyrate 11b,17,21-trihydroxypregn-4-ene-3,20-dione 17-butyrate 11BETA,17,21-TRIHYDROXYPREGN-4-ENE-3,20-DIONE 17-BUTYRATE (11beta)-11,21-dihydroxy-3,20-dioxopregn-4-en-17-yl butanoate 11-beta,17-alpha,21-trihydroxy-4-pregnene-3,20-dione17-alpha-butyrate (9xi,11beta,14xi)-11,21-dihydroxy-3,20-dioxopregn-4-en-17-yl butanoate |
| CAS | 13609-67-1 |
| EINECS | 237-093-4 |
| InChI | InChI=1/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18?,19-,22?,23-,24-,25-/m0/s1 |
13609-67-1 - Physico-chemical Properties
| Molecular Formula | C25H36O6 |
| Molar Mass | 432.56 |
| Density | 1.0914 (rough estimate) |
| Melting Point | 210.0 to 214.0 °C |
| Boling Point | 466.2°C (rough estimate) |
| Flash Point | 194°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 3.76E-16mmHg at 25°C |
| Appearance | neat |
| Color | White to Off-White |
| Merck | 14,4787 |
| pKa | 12.98±0.10(Predicted) |
| Storage Condition | Refrigerator |
| Refractive Index | 1.4593 (estimate) |
| MDL | MFCD00083364 |
13609-67-1 - Risk and Safety
| WGK Germany | 2 |
| RTECS | GM9002000 |
| HS Code | 2937290000 |
13609-67-1 - Standard
Authoritative Data Verified Data
This product is (11B)-11,17,21-trihydroxyprogestin -4-ene -3, 20-diketo-17a-butyrate. Based on the dry product, the content of C25H36O6 should be 97.0% ~ 102.0%.
Last Update：2024-01-02 23:10:35
13609-67-1 - Trait
Authoritative Data Verified Data
- This product is white or white crystalline powder; Odorless.
- This product is soluble in three gas methane, dissolved in methanol, slightly soluble in anhydrous ethanol, very slightly soluble in ether, almost insoluble in water.
specific rotation
take this product, precision weighing, plus three gas methane dissolution and quantitative dilution of each lml containing about 10 mg of the solution, according to the law (General 0621), the specific rotation was 47 ° to 54 °.
Last Update：2022-01-01 11:30:36
13609-67-1 - Differential diagnosis
Authoritative Data Verified Data
- take about 4mg of this product, add 2ml sulfuric acid to dissolve, that is, yellow to brown yellow, with green fluorescence.
- take about 10mg of this product, add methanol lml to dissolve, Add alkaline copper tartrate test solution lml, heating, that is, the red precipitate of cuprous oxide.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 585).
Last Update：2022-01-01 11:30:36
13609-67-1 - Exam
Authoritative Data Verified Data
Related substances
take about 15mg of this product, put it in a 50ml measuring flask, add an appropriate amount of mobile phase to shake to dissolve, dilute to the scale with mobile phase, shake well, and use as a test solution; take 1ml accurately, put it in a 50ml measuring flask, dilute it to the scale with mobile phase, shake it well, and use it as a control solution. According to the chromatographic conditions under the content determination item, 20 u1 of the test solution and the control solution are accurately measured, and the human liquid chromatograph is injected respectively, and the chromatogram is recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (1.0%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (2.0%). The peaks in the chromatogram of the test solution which were 0.02 times smaller than the main peak area of the control solution were ignored.
loss on drying
take this product, at 75°C under reduced pressure drying to constant weight, weight loss should not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of ignition residue shall not contain more than 20 parts per million of heavy metal after examination by law (General rule 0821, Law II).
Last Update：2022-01-01 11:30:37
13609-67-1 - Content determination
Authoritative Data Verified Data
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Water-acetonitrile-glacial acetic acid (55:45:0.5) as mobile phase; The detection wavelength was 240mn. The number of theoretical plates shall not be less than 1500 calculated by hydrocortisone butyrate peak, and the resolution between hydrocortisone butyrate peak and internal standard substance peak shall meet the requirements. Preparation of internal standard solution methyltestosterone was taken, dissolved in methanol and diluted to prepare a solution containing about 0.18mg per 1 ml.
- determination method: take this product, weigh it precisely, dissolve it with methanol and dilute it quantitatively to make a solution containing about 0.26mg in μl ml. Take 5ml of the solution and 5ml of the internal standard solution precisely, put 50ml measuring flask, dilute to the scale with methanol, shake well, take 2u1 and inject human liquid chromatograph, record chromatogram; Take hydrocortisone butyrate reference substance, determine with the same method. According to the internal standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:30:38
13609-67-1 - Category
Authoritative Data Verified Data
adrenocortical hormone drugs.
Last Update：2022-01-01 11:30:38
13609-67-1 - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:30:38
13609-67-1 - Hydrocortisone Butyrate Cream
Authoritative Data Verified Data
This product contains hydrocortisone butyrate (C25H3606) should be 90.0% to 110.0% of the label.
trait
This product is white cream.
identification
In the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.
examination
should comply with the relevant provisions under Cream (General rule 0109).
Content determination
take an appropriate amount of this product (about equivalent to 1.3mg of hydrocortisone butyrate), weigh it accurately, add 15ml of methanol, heat it in 50m1 water bath, stir to dissolve hydrocortisone butyrate, and let it cool, add 5ml of internal standard solution accurately, dilute to 50ml quantitatively with methanol, shake well, cool in an ice bath for more than 2 hours, remove, rapidly filter, and continue to cool the filtrate, as a test solution, take 20ul as the method under the item of hydrocortisone butyrate content determination, that is obtained.
category
hydrocortisone isobutyrate.
specification
10g : lOmg
storage
protected from light, sealed, stored in a cool place.
Last Update：2022-01-01 11:30:39
Supplier List
Spot supply
Product Name: Hydrocortisone Impurity 16 Request for quotationCAS: 13609-67-1
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Spot supply
Product Name: (8S,9S,10R,11S,13S,14S,17R)-11-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ylbutyrate Request for quotationCAS: 13609-67-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Hydrocortisone Butyrate Visit Supplier Webpage Request for quotationCAS: 13609-67-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Cortisol 17-butyrate; Hydrocortisone butyrate Visit Supplier Webpage Request for quotationCAS: 13609-67-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Hydrocortisone butyrate Visit Supplier Webpage Request for quotationCAS: 13609-67-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Multiple Specifications
Product Name: Hydrocortisone Butyrate Visit Supplier Webpage Request for quotationCAS: 13609-67-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Hydrocortisone Impurity 16 Request for quotationCAS: 13609-67-1
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Spot supply
Product Name: (8S,9S,10R,11S,13S,14S,17R)-11-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ylbutyrate Request for quotationCAS: 13609-67-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Hydrocortisone Butyrate Visit Supplier Webpage Request for quotationCAS: 13609-67-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Cortisol 17-butyrate; Hydrocortisone butyrate Visit Supplier Webpage Request for quotationCAS: 13609-67-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Hydrocortisone butyrate Visit Supplier Webpage Request for quotationCAS: 13609-67-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Multiple Specifications
Product Name: Hydrocortisone Butyrate Visit Supplier Webpage Request for quotationCAS: 13609-67-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History