136656-07-0
Timosaponin B II
CAS: 136656-07-0
Molecular Formula: C45H76O19
136656-07-0 - Names and Identifiers
| Name | Timosaponin B II |
| Synonyms | Timosaponin B2 Timsaponin B-Ⅱ Timosaponin BII Timosaponin Bii timosaponin B-II Timosaponin B II Prototimosaponin A III (25S)-26-(β-D-Glucopyranosyloxy)-3β-[(2-O-β-D-glucopyranosyl-β-D-galactopyranosyl)oxy]-5β-furostan-22-ol (25S)-3β-[(2-O-β-D-Glucopyranosyl-β-D-galactopyranosyl)oxy]-26-(β-D-glucopyranosyloxy)-5β-furostane-22-ol β-D-Galactopyranoside, (3β,5β,22α,25S)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl- |
| CAS | 136656-07-0 |
| InChI | InChI=1/C45H76O19/c1-19(18-58-40-37(55)34(52)31(49)27(15-46)60-40)7-12-45(57)20(2)30-26(64-45)14-25-23-6-5-21-13-22(8-10-43(21,3)24(23)9-11-44(25,30)4)59-42-39(36(54)33(51)29(17-48)62-42)63-41-38(56)35(53)32(50)28(16-47)61-41/h19-42,46-57H,5-18H2,1-4H3/t19-,20-,21+,22-,23+,24-,25-,26-,27+,28+,29+,30-,31+,32+,33-,34-,35-,36-,37+,38+,39+,40+,41-,42+,43-,44-,45?/m0/s1 |
136656-07-0 - Physico-chemical Properties
| Molecular Formula | C45H76O19 |
| Molar Mass | 921.08 |
| Density | 1.43 |
| Boling Point | 1033.6±65.0 °C(Predicted) |
| Flash Point | 573℃ |
| Solubility | DMSO:100 mg/mL (108.56 mM) |
| Appearance | White powder |
| pKa | 12.85±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.627 |
| MDL | MFCD30179489 |
| Physical and Chemical Properties | Soluble in methanol, ethanol, DMSO and other organic solvents, derived from Anemarrhena Anemarrhena asphodeloides. |
| In vitro study | Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC 50 value of 15.5 μg/mL in the HL-60 cells. |
| In vivo study | Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time. |
136656-07-0 - Risk and Safety
| HS Code | 29389090 |
136656-07-0 - Reference
| Reference Show more | 1. Ni Wenpeng, Zhu Min, Zhou Qinmei. Determination of Two Anemarrhena Saponins in Zishen Customs Clearance Capsule by HPLC-ELSD Method [J]. Jiangsu Traditional Chinese Medicine 2012(11):69-70. 2. Zhang Shengan, Tao Chunxiao, Lu Lu, Jiang Min, Zhou Guoliang, Ding Yue. Effect of Biological Enzymatic Solution on Antifungal Effect of Anemarrhena asmoides [J]. Journal of Shanghai University of Traditional Chinese Medicine, 2019,33(05):67-72. 3. Liu Yanping, Ding Yue, Zhang Tong, et al. Extraction of Anemarrhena asphosenoside B Ⅱ and Purification of Macroporous Resin [J]. Traditional Chinese Medicine, 2013(06):994-998. 4. [IF = 2.289] Zhou Shun et al."Anthelmintic efficacy of natural saponins against Gyrodactylus kobayashii in goldfish (Carassius auratus) and their 3D-QSAR analysis." Parasitol Res. 2021 Mar;120(3):1143-1150 |
136656-07-0 - Reference Information
| biological activity | Timosaponin BII (Prototimosaponin A III) is A steroidal saponin found in the rhizomes of anemarrhenae. Timosaponin BII has neuroprotective, anti-inflammatory and antioxidant activities. |
| in vitro study | Timosaponin BII is a sterotal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the propagation of HL-60 (leucemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC 50 value of 15.5 μg/mL in the HL-60 cells. |
| in vivo study | Rat retinas in model group and vehicle control group manifest. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are incremental. House, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time. |
| Chemical properties | is soluble in methanol, ethanol, DMSO and other organic solvents, and is derived from Anemarrhena asphodeloides. |
| Use | timosaponin B Ⅱ has the effect of inhibiting platelet aggregation. |
Last Update：2024-04-09 20:48:19
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