1369773-39-6
AHU-377 hemicalcium salt
CAS: 1369773-39-6
Molecular Formula: C48H56CaN2O10
1369773-39-6 - Names and Identifiers
1369773-39-6 - Physico-chemical Properties
| Molecular Formula | C48H56CaN2O10 |
| Molar Mass | 861.04364 |
| Melting Point | >140°C (dec.) |
| Solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | -20°C |
| In vitro study | Sacubitril (AHU-377) is a single molecule that is comprised of molecular moieties of valsartan, an ARB, and Sacubitril hemicalcium salt, a neprilysin inhibitor (1:1 ratio). Sacubitril (AHU-377) is converted by enzymatic cleavage of the ethyl ester into the active neprilysin inhibiting metabolite LBQ657. The inactive NEPi precursor, Sacubitril hemicalcium salt, does not inhibit collagen accumulation in fibroblasts nor cardiac myocyte hypertrophy. In cardiac fibroblasts, the active NEPi LBQ657 had no discernible effects. In contrast, LBQ657 modestly inhibits cardiac myocyte hypertrophy. |
| In vivo study | In humans, Sacubitril (AHU-377)(t max 0.5-1.1 h) are absorbed quickly. Sacubitril hemicalcium salt is converted rapidly into LBQ657 with its t max being reached in 1.9-3.5 h. Mean t 1/2 values for the biologically active LBQ657 is 9.9-11.1 h.In vehicle-treated dogs, ANF increases urinary sodium excretion from 17.3±3.6 to 199.5±18.4 pequivkglmin. This effect is potentiated significantly in animals which receive Sacubitril (AHU-377). Urinary volume is also potentiated in animals which receive an iv administration of Sacubitril (AHU-377). |
1369773-39-6 - Risk and Safety
| UN IDs | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all |
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View History
1369773-39-6
1-氮杂双环[2.2.2]辛烷
2-Methyl-4-pentanone oxime
133562-28-4
218278-58-1
1316755-16-4
361441-96-5
169275-01-8
1445379-61-2
68954-91-6
1-氮杂双环[2.2.2]辛烷
2-Methyl-4-pentanone oxime
133562-28-4
218278-58-1
1316755-16-4
361441-96-5
169275-01-8
1445379-61-2
68954-91-6