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144689-24-7

4-(2-Hydroxy-2-propanyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylic acid

CAS: 144689-24-7

Molecular Formula: C24H26N6O3

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144689-24-7 - Names and Identifiers

Name 4-(2-Hydroxy-2-propanyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylic acid
Synonyms CS 088
CS-415
Olmesartan
Olmesartan Acid
Olmesartan Medoxomil-1
Olmesartan (Olmesartan Medoxomil EP Impurity A)
4-(2-Hydroxy-2-propanyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylic acid
4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid
4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
1H-Imidazole-5-carboxylicacid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
CAS 144689-24-7
EINECS 646-413-5
InChI InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)

144689-24-7 - Physico-chemical Properties

Molecular FormulaC24H26N6O3
Molar Mass446.5
Density1.33
Melting Point186-188°C
Boling Point738.3±70.0 °C(Predicted)
Flash Point400.3°C
Solubility Soluble in DMSO (20 mM), methanol (sparingly), and tetrahydrofuran.
Vapor Presure6.89E-23mmHg at 25°C
AppearanceWhite solid
Colorwhite to beige
pKa2.39±0.50(Predicted)
Storage Condition2-8°C
StabilityHygroscopic
Refractive Index1.671
UseAn angiotensin II (AT1) receptor antagonist
In vivo study Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species.

144689-24-7 - Risk and Safety

RTECSNI4014100
HS Code29339900

144689-24-7 - Introduction

Olmesartan Acid is an angiotensin II receptor antagonist that prevents the binding of angiotensin II, thus preventing vasoconstriction.
Last Update：2022-10-16 17:13:58

144689-24-7 - Reference Information

overview olmesartan is olmesartan medoxomil EP impurity a. Olmesartan medoxomil is a new angiotensin (AT) receptor antagonist, which was first approved by the US FDA for the treatment of hypertension in May 2002.
biological activity Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist, commonly used in hypertension related research.
Cell Line: Human cervical cancer cell line (HeLa)
Concentration: 0.7- 5 mM
Incubation Time: 24, 48 and 72 h
Result: IC 50 s against HeLa cell line are 4.685 and 1.651 mM for 48 and 72 h, respectively.
use hypertension. among all kinds of drugs for treating hypertension, ARB has become the drug with the fastest increase in application ratio. the important reason is the effectiveness and good safety of these drugs (except pregnant women)
toxic substance data information provided by: pubchem.ncbi.nlm.nih.gov (external link)
Last Update：2024-04-09 15:16:47
144689-24-7
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Email: product@acmec-e.com
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SKYRUN INDUSTRIAL CO.,LTD
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Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
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Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
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CAS: 144689-24-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
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