146374-27-8
2-methylpropane-2-sulfinamide
CAS: 146374-27-8
Molecular Formula: C4H11NOS
146374-27-8 - Names and Identifiers
146374-27-8 - Physico-chemical Properties
| Molecular Formula | C4H11NOS |
| Molar Mass | 121.2 |
| Density | 1.124 |
| Melting Point | 97-101°C(lit.) |
| Boling Point | 220.0±23.0 °C(Predicted) |
| Flash Point | 86.8°C |
| Solubility | Soluble in methanol. |
| Vapor Presure | 0.116mmHg at 25°C |
| Appearance | Bright yellow crystal |
| Color | White to tan |
| pKa | 10.11±0.50(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.523 |
| MDL | MFCD05861480 |
146374-27-8 - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29309090 |
146374-27-8 - Reference Information
| use | tert-butyl sulfinamide as a chiral auxiliary has the following advantages: (1) it is easy to form imines with various aldehydes or ketones;. (2) Due to the activation of tert-butyl sulfinyl, the generated imine has stronger electrophilicity and is easier to react with nucleophiles or be reduced by metal boron reagents, induce high diastereoselectivity; (3) In the addition product, tert-butyl sulfonyl is also a good protective group, which can withstand strong bases and transition metals in the reaction; (4) Under acidic conditions, tert-butyl sulfonyl groups are easily removed, and the obtained hydrochloride can be purified with ether solvents, and the yield is almost quantitative. Synthesis of 4-sulfonyliminopiperidine, and it can react with benzyl Grignard reagent to form an important pharmaceutical structural unit 4-benzyl-4-aminopiperidine. 1 can also be used to insert methylene into derivatized sulfonylimide to prepare spirotoluenesulfonyl azepine. |
Last Update：2024-04-10 22:29:15
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