149771-43-7

149771-43-7 - Names and Identifiers

Name	TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE
Synonyms	3-Benzyl-8-Boc-3,8-diaza-bicyclo[3.2.1]octane TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE 3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 3-(phenylMethyl)-, 1,1-diMethylethyl ester
CAS	149771-43-7

149771-43-7 - Physico-chemical Properties

Molecular Formula	C18H26N2O2
Molar Mass	302.41
Storage Condition	2-8°C
Use	Uses 3-benzyl-8-(tert-butoxycarbonyl)-3, 8-diazabicyclo [3.2.1]-octane is a hydrocarbon derivative, which can be used as a pharmaceutical intermediate.

149771-43-7 - Upstream Downstream Industry

Raw Materials

D-Proline, 1-(phenylmethyl)-5-[[(phenylmethyl)amino]carbonyl]-, ethyl ester, (5S)-
3-BENZYL-3,8-DIAZABICYCLOOCTANE[3.2.1]-2,4-DIONE
3,8-dibenzyl-3,8-diazabicyclo[3.2.1]octane-2,4-dione
Diethyl meso-2,5-dibromoadipate
8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE
(1-Benzylpyrrolidine-2,5-diyl)diMethanol
1-BOC-2,5-BIS-HYDROXYMETHYL-PYRROLIDINE
tert-butyl 2,5-bis(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate
diethyl 1-benzylpyrrolidine-2,5-dicarboxylate
3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE
DIETHYL 1-BENZYLPYRROLIDINE-2,5-DICARBOXYLATE
Benzaldehyde
Di-tert-butyl dicarbonate
Sodium bicarbonate
Benzyl bromide

149771-43-7 - Preparation

3, 8-diazabicyclo [3.2.1] octane -8-formic acid tert-butyl ester (0.5g,2.4mmol), benzyl bromide (0.31mL,2.6mmol) and triethylamine (0.5 ml,3.6mmol) were sequentially added into a 100mL single-mouth bottle, dissolved with acetonitrile (20mL), and gradually heated to 50 ℃ for 5 hours under nitrogen protection. The reaction solution is cooled to room temperature and then poured into tap water, ethyl acetate is extracted (60mL × 3), and the organic phase is then washed with tap water, saturated salt water, and dried with anhydrous sodium sulfate. The crude product was obtained by filtration and evaporation, and purified by column chromatography (petroleum ether/ethyl acetate (v/v)= 40/1-20/1) to obtain 3-benzyl -8-(tert-butoxycarbonyl)-3, 8-diazabicyclo [3.2.1]-octane as a white solid (0.68g,90%).

Last Update：2024-04-10 22:29:15

149771-43-7 - Reference Information

use

3-benzyl -8-(tert-butoxycarbonyl)-3,8-diazabicyclo [3.2.1]-octane is a hydrocarbon derivative and can be used as a pharmaceutical intermediate.

preparation

3,8-diazabicyclo [3.2.1] octane -8-tert-butyl formate (0.5g,2.4mmol), benzyl bromide (0.31mL,2.6mmol), triethylamine (0.5
ml,3.6mmol) was sequentially added into a 100mL single-mouth bottle, dissolved with acetonitrile (20mL), and gradually heated to 50 ℃ under nitrogen protection for 5
hours. The reaction solution is cooled to room temperature and then poured into tap water, ethyl acetate is extracted (60mL × 3), and the organic phase is then washed with tap water, saturated salt water, and dried with anhydrous sodium sulfate. The crude product was obtained by filtration and evaporation, and purified by column chromatography (petroleum ether/ethyl acetate (v/v)= 40/1-20/1) to obtain 3-benzyl -8-(tert-butoxycarbonyl)-3, 8-diazabicyclo [3.2.1]-octane as a white solid (0.68g,90%).

Last Update：2024-04-09 19:05:04