164178-33-0
AM 630
CAS: 164178-33-0
Molecular Formula: C23H25IN2O3
164178-33-0 - Names and Identifiers
164178-33-0 - Physico-chemical Properties
| Molecular Formula | C23H25IN2O3 |
| Molar Mass | 504.36 |
| Density | 1.49±0.1 g/cm3(Predicted) |
| Boling Point | 605.9±55.0 °C(Predicted) |
| Solubility | DMSO: >5mg/mL |
| Appearance | powder |
| Color | white to beige |
| pKa | 6.98±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | The AM251 and 6-Iodopravadoline (AM630)-evoked Ca 2+ influxes into TG sensory neurons aere concentration-dependent, and fitted. The EC 50 for AM251 and 6-Iodopravadoline are 7.37 μM and 15.6 μM, respectively. AM251 and 6-Iodopravadoline activate TRPA1 in TG sensory neurons. 6-Iodopravadoline is comparable in value in both TRPA1 and TRPV1/TRPA1 expressing CHO cells (2 and 4.6 μM, respectively). AM251 and 6-Iodopravadoline activation of TRPA1 is modulated by TRPV1. 6-Iodopravadoline (0, 50, 100, and 200 nM) is not toxic to RAW264.7 cells. 6-Iodopravadoline (100 nM) substantially inhibits osteoclastogenesis in cultures with RANKL and Ti particles in a dose-dependent manner. 6-Iodopravadoline (1 μM) blocks the CP-55,940 dose response with EC 50 of 170 nM at human and EC 50 of 110 nM at rat cannabinoid CB2 receptor. |
| In vivo study | 6-Iodopravadoline (AM630) (2, 3 mg/kg, i.p.) significantly reduces the time spent in the light box compared with vehicle group. 6-Iodopravadoline (AM630) (1, 2 or 3 mg/kg, i.p., twice a day) produces a significant anxiolytic effect, increasing the time spent in the light box at all of the doses used. |
164178-33-0 - Risk and Safety
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 50 - Very Toxic to aquatic organisms |
| Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
164178-33-0 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.983 ml | 9.914 ml | 19.827 ml |
| 5 mM | 0.397 ml | 1.983 ml | 3.965 ml |
| 10 mM | 0.198 ml | 0.991 ml | 1.983 ml |
| 5 mM | 0.04 ml | 0.198 ml | 0.397 ml |
Last Update：2024-01-02 23:10:35
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Product Name: AM630 Visit Supplier Webpage Request for quotationCAS: 164178-33-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
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Product Name: AM630 Request for quotationCAS: 164178-33-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: AM630 Visit Supplier Webpage Request for quotationCAS: 164178-33-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
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Product Name: AM 630 Visit Supplier Webpage Request for quotation
CAS: 164178-33-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 164178-33-0
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Email: 3008007409@qq.com
Mobile: 18021002903
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View History
164178-33-0
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