2-Fluoro-6-hydroxybenzonitrile
2-Fluoro-6-hydroxybenzonitrile
CAS: 140675-43-0
Molecular Formula: C7H4FNO
2-Fluoro-6-hydroxybenzonitrile - Names and Identifiers
| Name | 2-Fluoro-6-hydroxybenzonitrile |
| Synonyms | 2-Cyano-3-fluorophenol 6-FLUOROSALICYLONITRILE 2-fuoro-6-hydroxybenzonitrle 2-fluoro-6-hydroxybenzonitrle 2-Fluoro-6-hydroxybenzonitrile 2-FLUORO-6-HYDROXYBENZONITRILE Benzonitrile, 2-fluoro-6-hydroxy- (9CI) 2-Cyano-3-fluorophenol, 6-Fluorosalicylonitrile |
| CAS | 140675-43-0 |
| EINECS | 642-487-8 |
| InChI | InChI=1/C8H5FO/c1-2-6-7(9)4-3-5-8(6)10/h1,3-5,10H |
2-Fluoro-6-hydroxybenzonitrile - Physico-chemical Properties
| Molecular Formula | C7H4FNO |
| Molar Mass | 137.11 |
| Density | 1.34±0.1 g/cm3(Predicted) |
| Melting Point | 156-158°C |
| Boling Point | 257.5±25.0 °C(Predicted) |
| Appearance | White solid |
| BRN | 8403914 |
| pKa | 6.17±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.56 |
| MDL | MFCD03428592 |
2-Fluoro-6-hydroxybenzonitrile - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R20/22 - Harmful by inhalation and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 3276 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
2-Fluoro-6-hydroxybenzonitrile - Introduction
2-Fluoro-6-hydroxybenzonitrile is an organic compound with the chemical formula C7H5FNO. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Colorless or light yellow crystalline solid
-melting point: 121-123 ℃
-Boiling point: 282 ℃
-Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and dimethyl sulfoxide
Use:
-2-Fluoro-6-hydroxybenzonitrile can be used as an intermediate in organic synthesis and is often used to prepare biologically active compounds.
-It can be used to prepare organic compounds such as medicines, pesticides and dyes.
Preparation Method:
There are many methods for preparing 2-fluoro-6-hydroxybenzonitrile, one of which is commonly used by fluorination reaction of 2-amino-6-hydroxyphenol. Specific steps are as follows:
1. first dissolve 2-amino -6-hydroxy phenol under acidic conditions.
2. Add a fluorinating agent, such as potassium hydrogen fluoride (KF).
3. Reaction at appropriate temperature and reaction time.
4. Filtration, washing, crystallization purification to obtain 2-fluoro-6-hydroxybenzonitrile.
Safety Information:
-2-Fluoro-6-hydroxybenzonitrile is an organic compound and needs to be operated safely. Wear chemical protective gloves and goggles during use and keep good ventilation.
-Avoid inhalation, ingestion and contact with skin and eyes. In case of contact, rinse immediately with plenty of water and seek medical help.
-During storage and handling, please follow the correct chemical storage methods and keep them away from ignition and oxidizing agents.
-Detailed safety information can refer to the relevant safety data sheet.
Nature:
-Appearance: Colorless or light yellow crystalline solid
-melting point: 121-123 ℃
-Boiling point: 282 ℃
-Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and dimethyl sulfoxide
Use:
-2-Fluoro-6-hydroxybenzonitrile can be used as an intermediate in organic synthesis and is often used to prepare biologically active compounds.
-It can be used to prepare organic compounds such as medicines, pesticides and dyes.
Preparation Method:
There are many methods for preparing 2-fluoro-6-hydroxybenzonitrile, one of which is commonly used by fluorination reaction of 2-amino-6-hydroxyphenol. Specific steps are as follows:
1. first dissolve 2-amino -6-hydroxy phenol under acidic conditions.
2. Add a fluorinating agent, such as potassium hydrogen fluoride (KF).
3. Reaction at appropriate temperature and reaction time.
4. Filtration, washing, crystallization purification to obtain 2-fluoro-6-hydroxybenzonitrile.
Safety Information:
-2-Fluoro-6-hydroxybenzonitrile is an organic compound and needs to be operated safely. Wear chemical protective gloves and goggles during use and keep good ventilation.
-Avoid inhalation, ingestion and contact with skin and eyes. In case of contact, rinse immediately with plenty of water and seek medical help.
-During storage and handling, please follow the correct chemical storage methods and keep them away from ignition and oxidizing agents.
-Detailed safety information can refer to the relevant safety data sheet.
Last Update：2024-04-09 19:05:46
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View History
2-Fluoro-6-hydroxybenzonitrile
175276-50-3
170366-90-2
BOC-Val-OSu
Calcium selenite
(3-AMINOPROPYL)DIPHENYLPHOSPHINE
FEMA 3320
175276-50-3
170366-90-2
BOC-Val-OSu
Calcium selenite
(3-AMINOPROPYL)DIPHENYLPHOSPHINE
FEMA 3320