200000-59-5

200000-59-5 - Names and Identifiers

Name	(2R,3S)-2-[(1R)-l-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-morpholine, 4-Methylbenzenesulfonate
Synonyms	-1-(3,5-Bis(trifluoromethyl) (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methyl (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]-ethoxy]-3-(4-fluorophenyl)morpholine tosylate (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methylben (2R,3S)-2-((R)-1-(3,5-Bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine 4-Methylbenzenesulfonate (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate (2R,3S)-2-[(1R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethoxy]-3-(4-Fluorophenyl)Morpholine 4-Methylbenzenesulfonate (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate (2R,3S)-2-[(1R)-l-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-morpholine, 4-Methylbenzenesulfonate Morpholine,2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-,(2R,3S)-, 4-methylbenzenesulfonate (2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine,4-methylbenzenesulfonic acid Morpholine, 2-[(1R)-1-[3,5-bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2R,3S)-, 4-Methylbenzenesulfonate
CAS	200000-59-5
InChI	InChI=1S/C20H18F7NO2.C7H8O3S/c1-11(13-8-14(19(22,23)24)10-15(9-13)20(25,26)27)30-18-17(28-6-7-29-18)12-2-4-16(21)5-3-12;1-6-2-4-7(5-3-6)11(8,9)10/h2-5,8-11,17-18,28H,6-7H2,1H3;2-5H,1H3,(H,8,9,10)/t11-,17+,18-;/m1./s1

200000-59-5 - Physico-chemical Properties

Molecular Formula	C27H26F7NO5S
Molar Mass	609.56
Appearance	Solid
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Sensitive	IRRITANT
MDL	MFCD13183777

200000-59-5 - Introduction

(2R,3S)-2-[(1R)-l-[3,5-bis (trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-morpholine, 4-Methylbenzenesulfonate is an organic compound. Its Properties, Uses, preparation methods and safety information are as follows:

Nature:
-chemical formula: C23H23F5NO3S
-Appearance: White solid
-Melting point: About 150-155 ° C
-Solubility: Slightly soluble in water, soluble in organic solvents such as acetonitrile, dimethyl sulfoxide and chloroform

Use:
(2R,3S)-2-[(1R)-l-[3,5-bis (trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-morpholine, 4-Methylbenzenesulfonate is widely used in the field of medicine, mainly as a synthetic intermediate of chiral drugs. It can be used to synthesize biologically active compounds, such as anti-inflammatory drugs and anti-cancer drugs.

Method:
(2R,3S)-2-[(1R)-l-[3,5-bis (trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-morpholine, the preparation of 4-Methylbenzenesulfonate typically involves a multi-step reaction. A common synthesis method includes the following steps:
1. Benzene sulfonic acid with (2R,3S)-2-[(1R)-1-[3,5-bis (trifluoromethyl)) phenyl] ethoxy]-3-(4-fluorophenyl) morpholine reacts to generate (2R,3S)-2-[(1R)-1-[3, 5-Bis (trifluoromethyl) phenyl] ethoxy]-3-(4-fluorophenyl) morpholine benzenesulfonate.
2. The resulting compound is purified and crystallized to obtain the final product.

Safety Information:
About (2R,3S)-2-[(1R)-l-[3,5-bis (trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-morpholine, specific safety information on 4-Methylbenzenesulfonate requires reference to the safety data sheet of the relevant chemical and the safety instructions provided by the chemical supplier. Appropriate laboratory practices and personal protective measures should be taken to comply with relevant safety regulations when handling and using chemicals.

Last Update：2024-04-09 21:54:55