209328-72-3
5-chloro-6-fluoropyridin-3-ol
CAS: 209328-72-3
Molecular Formula: C5H3ClFNO
209328-72-3 - Names and Identifiers
209328-72-3 - Physico-chemical Properties
| Molecular Formula | C5H3ClFNO |
| Molar Mass | 147.53 |
| Density | 1.517 |
| Boling Point | 354.4±37.0 °C(Predicted) |
| Flash Point | 168.1°C |
| Vapor Presure | 1.65E-05mmHg at 25°C |
| Appearance | Solid |
| pKa | 8.25±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.552 |
209328-72-3 - Introduction
Is an organic compound with the chemical formula C5H3ClFNO, which is a white crystalline solid. The following is a detailed description of the properties, uses, methods of manufacture and safety information:
Nature:
-Appearance: White crystalline solid.
-Solubility: It is not easily soluble with water, but can be dissolved in organic solvents, such as ethanol and methyl ether.
-Melting point: Its melting point is about 74-80°C.
-Chemical properties: It is a compound containing hydroxyl, chlorine and fluorine atoms, and has certain chemical reactivity.
Use:
-Pharmaceutical field: As a drug intermediate, it can be used to synthesize a variety of drugs, such as antibiotics and antiviral drugs.
-Pesticide field: It can also be used as a raw material for pesticides to prevent and control plant diseases and insect pests.
Method:
There are various preparation methods, the following is a common preparation method:
First, 2-amino-5-hydroxypyridine is reacted with trifluoroacetic acid to produce 2-trifluoroacetyl-5-hydroxypyridine. Then 2-trifluoroacetyl -5-hydroxyl pyridine and chlorinated carbonyl reaction, you can get.
Safety Information:
-should be away from fire and high temperature, avoid contact with strong oxidants.
-Wear appropriate protective equipment, such as chemical protective gloves and masks, to ensure that the operation is carried out in a well-ventilated place.
-In case of accidental ingestion or inhalation, seek medical advice immediately and show this safety data sheet.
-During storage, store it in a dry, cool, well-ventilated place away from direct sunlight.
Nature:
-Appearance: White crystalline solid.
-Solubility: It is not easily soluble with water, but can be dissolved in organic solvents, such as ethanol and methyl ether.
-Melting point: Its melting point is about 74-80°C.
-Chemical properties: It is a compound containing hydroxyl, chlorine and fluorine atoms, and has certain chemical reactivity.
Use:
-Pharmaceutical field: As a drug intermediate, it can be used to synthesize a variety of drugs, such as antibiotics and antiviral drugs.
-Pesticide field: It can also be used as a raw material for pesticides to prevent and control plant diseases and insect pests.
Method:
There are various preparation methods, the following is a common preparation method:
First, 2-amino-5-hydroxypyridine is reacted with trifluoroacetic acid to produce 2-trifluoroacetyl-5-hydroxypyridine. Then 2-trifluoroacetyl -5-hydroxyl pyridine and chlorinated carbonyl reaction, you can get.
Safety Information:
-should be away from fire and high temperature, avoid contact with strong oxidants.
-Wear appropriate protective equipment, such as chemical protective gloves and masks, to ensure that the operation is carried out in a well-ventilated place.
-In case of accidental ingestion or inhalation, seek medical advice immediately and show this safety data sheet.
-During storage, store it in a dry, cool, well-ventilated place away from direct sunlight.
Last Update：2024-04-09 21:01:54
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