220239-65-6
[4-Fluoro-3-(trifluoromethyl)phenyl]acetonitrile
CAS: 220239-65-6
Molecular Formula: C9H5F4N
220239-65-6 - Names and Identifiers
220239-65-6 - Physico-chemical Properties
| Molecular Formula | C9H5F4N |
| Molar Mass | 203.14 |
| Density | 1.324±0.06 g/cm3(Predicted) |
| Boling Point | 93°C 10mm |
| Flash Point | 114.8°C |
| Vapor Presure | 0.0832mmHg at 25°C |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.443 |
220239-65-6 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3276 |
| Hazard Class | TOXIC |
220239-65-6 - Introduction
[4-Fluoro-3-(trifluoromethyl)phenyl]acetonitrile is an organic compound with the chemical formula C9H4F4N. Its molecular structure contains a cyano group and a benzyl group, wherein the benzyl group is also attached to a fluorine containing substituent and a trifluoromethyl group. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance:[4-Fluoro-3-(trifluoromethyl)phenyl]acetonitrile is a white to pale yellow crystalline solid.
-Solubility: It is almost insoluble in water and soluble in common organic solvents such as ethanol and dimethyl sulfoxide.
-Melting point: About 85-89 ° C.
-Thermal stability:[4-Fluoro-3-(trifluoromethyl)phenyl]acetonitrile can be stable at high temperatures.
Use:
-as an important intermediate in Organic Synthesis:[4-Fluoro-3-(trifluoromethyl)phenyl]acetonitrile can be used as an important intermediate in organic synthesis for the preparation of other organic compounds, such as drugs, pesticides and functional materials, etc.
-Used in the field of medicine: It can be used in the synthesis of new anti-tumor drugs in drug research and development.
Method:
-Usually obtained by reacting 4-fluoro-3-(trifluoromethyl) phenylacetaldehyde with sodium cyanide under appropriate conditions.
-Specific steps: First, 4-fluoro-3-(trifluoromethyl) phenylacetaldehyde is reacted with sodium cyanide in a suitable solvent to generate the corresponding cyanide. Then, by acidification treatment, the cyanide is converted to [4-Fluoro-3-(trifluoromethyl)phenyl]acetonitrile.
Safety Information:
- [4-Fluoro-3-(trifluoromethyl)phenyl]acetonitrile is a chemical, and you need to pay attention to safe operation during use.
-specific safety information should refer to the safety technical instructions (SDS) provided by the chemical manufacturer and safety measures in accordance with local regulations.
Nature:
-Appearance:[4-Fluoro-3-(trifluoromethyl)phenyl]acetonitrile is a white to pale yellow crystalline solid.
-Solubility: It is almost insoluble in water and soluble in common organic solvents such as ethanol and dimethyl sulfoxide.
-Melting point: About 85-89 ° C.
-Thermal stability:[4-Fluoro-3-(trifluoromethyl)phenyl]acetonitrile can be stable at high temperatures.
Use:
-as an important intermediate in Organic Synthesis:[4-Fluoro-3-(trifluoromethyl)phenyl]acetonitrile can be used as an important intermediate in organic synthesis for the preparation of other organic compounds, such as drugs, pesticides and functional materials, etc.
-Used in the field of medicine: It can be used in the synthesis of new anti-tumor drugs in drug research and development.
Method:
-Usually obtained by reacting 4-fluoro-3-(trifluoromethyl) phenylacetaldehyde with sodium cyanide under appropriate conditions.
-Specific steps: First, 4-fluoro-3-(trifluoromethyl) phenylacetaldehyde is reacted with sodium cyanide in a suitable solvent to generate the corresponding cyanide. Then, by acidification treatment, the cyanide is converted to [4-Fluoro-3-(trifluoromethyl)phenyl]acetonitrile.
Safety Information:
- [4-Fluoro-3-(trifluoromethyl)phenyl]acetonitrile is a chemical, and you need to pay attention to safe operation during use.
-specific safety information should refer to the safety technical instructions (SDS) provided by the chemical manufacturer and safety measures in accordance with local regulations.
Last Update：2024-04-09 21:01:54
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CAS: 220239-65-6
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CAS: 220239-65-6
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