306936-57-2
3-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde
CAS: 306936-57-2
Molecular Formula: C10H7FN2O
306936-57-2 - Names and Identifiers
| Name | 3-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde |
| Synonyms | AKOS B000254 AKOS PAO-0297 CHEMBRDG-BB 4301174 ART-CHEM-BB B000254 3-(4-FLUOROPHENYL)PYRAZOLE-4-CARBOXALDEHYDE 3-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde 3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE 3-(4-Fluorophenyl)-1H-pyrazole-4-carboxaldehyde |
| CAS | 306936-57-2 |
| InChI | InChI=1/C10H7FN2O/c11-9-3-1-7(2-4-9)10-8(6-14)5-12-13-10/h1-6H,(H,12,13) |
306936-57-2 - Physico-chemical Properties
| Molecular Formula | C10H7FN2O |
| Molar Mass | 190.17 |
| Density | 1.337±0.06 g/cm3(Predicted) |
| Melting Point | 160 °C |
| Boling Point | 416.0±35.0 °C(Predicted) |
| Flash Point | 205.4°C |
| Vapor Presure | 3.96E-07mmHg at 25°C |
| pKa | 10.69±0.50(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | Air Sensitive |
| Refractive Index | 1.622 |
306936-57-2 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29331990 |
| Hazard Class | IRRITANT |
306936-57-2 - Introduction
3-(4-fluophenyl)-orophenyl is an organic compound with the chemical formula C10H7FN2O. It is a white to light yellow crystalline solid.
Nature:
-Appearance: White to light yellow crystalline solid
-Molecular weight: 198.17g/mol
-Melting Point: 110-112 ° C
-heat of fusion: 70.6-71.5 ° C
-Boiling point: 318.3 ° C
-Solubility: Soluble in some organic solvents, such as ethanol and dichloromethane
Use:
- 3-(4-fluorophenyl)-is useful as an important intermediate in organic synthesis.
-It is commonly used in drug synthesis and in the fields of pesticides and cosmetics.
Method:
The preparation of 3-(4-fluorophenyl)-fluorophenyl can be carried out by the following steps:
1. 4-fluorophenylboronic acid (4-fluorophenylboronic acid) was added to react with 4-nitrobenzoic acid methyl ester (4-nitrobenzyl nitrate) under alkaline conditions.
2. The product methyl 4-(4-fluorophenyl) benzoate (4-(4-fluorophenyl) benzoate) was reduced to the corresponding ketone by hydrogenation using hydrogen and a Pd/C catalyst.
3. React with urea to generate the target product 3-(4-fluorophenyl)-fluorol.
Safety Information:
According to the existing literature, 3-(4-fluorophenyl)-is generally considered to be relatively safe under correct operation and appropriate safety precautions. However, be sure to follow laboratory safety practices and use appropriate personal protective equipment, such as chemical gloves and safety glasses. At the same time, store it in a dry, cool place, avoid light and high temperature. Seek immediate medical help if exposed to or inhaled this compound.
Nature:
-Appearance: White to light yellow crystalline solid
-Molecular weight: 198.17g/mol
-Melting Point: 110-112 ° C
-heat of fusion: 70.6-71.5 ° C
-Boiling point: 318.3 ° C
-Solubility: Soluble in some organic solvents, such as ethanol and dichloromethane
Use:
- 3-(4-fluorophenyl)-is useful as an important intermediate in organic synthesis.
-It is commonly used in drug synthesis and in the fields of pesticides and cosmetics.
Method:
The preparation of 3-(4-fluorophenyl)-fluorophenyl can be carried out by the following steps:
1. 4-fluorophenylboronic acid (4-fluorophenylboronic acid) was added to react with 4-nitrobenzoic acid methyl ester (4-nitrobenzyl nitrate) under alkaline conditions.
2. The product methyl 4-(4-fluorophenyl) benzoate (4-(4-fluorophenyl) benzoate) was reduced to the corresponding ketone by hydrogenation using hydrogen and a Pd/C catalyst.
3. React with urea to generate the target product 3-(4-fluorophenyl)-fluorol.
Safety Information:
According to the existing literature, 3-(4-fluorophenyl)-is generally considered to be relatively safe under correct operation and appropriate safety precautions. However, be sure to follow laboratory safety practices and use appropriate personal protective equipment, such as chemical gloves and safety glasses. At the same time, store it in a dry, cool place, avoid light and high temperature. Seek immediate medical help if exposed to or inhaled this compound.
Last Update：2024-04-09 21:11:58
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View History
306936-57-2
74571-97-4
64689-22-1
108-26-9
53839-08-0
10397-30-5
15413-18-0
6789-80-6
745038-86-2
O-phenyl carbonochloridothioate
74571-97-4
64689-22-1
108-26-9
53839-08-0
10397-30-5
15413-18-0
6789-80-6
745038-86-2
O-phenyl carbonochloridothioate