3286-46-2
Sulbutiamine
CAS: 3286-46-2
Molecular Formula: C32H46N8O6S2
3286-46-2 - Names and Identifiers
3286-46-2 - Physico-chemical Properties
| Molecular Formula | C32H46N8O6S2 |
| Molar Mass | 702.89 |
| Density | 1.1323 (rough estimate) |
| Melting Point | 140.5-141.5 °C |
| Boling Point | 892.5±65.0 °C(Predicted) |
| Flash Point | 493.5°C |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 1.63E-32mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| Merck | 14,9297 |
| pKa | 5.82±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Hygroscopic |
| Refractive Index | 1.7400 (estimate) |
| Physical and Chemical Properties | The molecular formula of sulbuthiamine is C32H46N8O6S2, which is a vitamin B1 derivative developed by the French company Servier. The special drug patent 5921M states that this product is a preparation with Vitamin B1 activity, which can increase the content of vitamin B1 in blood and can treat all vitamin B1 deficiency. |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Sulbutiamine shows neuroprotective effects on hippocampal CA1 pyramidal neurons subjected to oxygen-glucose deprivation. Sulbutiamine enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH and GST activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF. |
3286-46-2 - Risk and Safety
| RTECS | LQ2721000 |
3286-46-2 - Reference Information
| biological activity | Sulbutiamine is a highly fat-soluble synthetic vitamin B1 analog, which can be used for the study of weakness. |
| category | toxic substances |
| toxicity classification | poisoning |
| acute toxicity | abdominal cavity-rat LD50: 660 mg/kg; Intravenous-rat LD50: 110 mg/kg |
| flammability hazard characteristics | flammability; thermal decomposition of toxic nitrogen oxides, sulfur oxide smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Last Update：2024-04-10 22:29:15
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