3321-92-4
3',5'-dichloro-2'-hydroxyacetophenone
CAS: 3321-92-4
Molecular Formula: C8H6Cl2O2
3321-92-4 - Names and Identifiers
3321-92-4 - Physico-chemical Properties
| Molecular Formula | C8H6Cl2O2 |
| Molar Mass | 205.04 |
| Density | 1.3806 (rough estimate) |
| Melting Point | 94-97°C(lit.) |
| Boling Point | 132-134°C18mm Hg(lit.) |
| Flash Point | 132-134°C/18mm |
| Solubility | soluble in Acetone |
| Vapor Presure | 0.000856mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Orange to Green |
| Maximum wavelength(λmax) | ['343nm(lit.)'] |
| BRN | 1638099 |
| pKa | 8.26±0.23(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.5490 (estimate) |
| MDL | MFCD00016417 |
3321-92-4 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29147000 |
| Hazard Note | Irritant |
3321-92-4 - Introduction
3 ',5'-dichloro-2 '-hydroxyacetophenone is an organic compound with the chemical formula C8H6Cl2O2. It is a white solid with a special aroma. The following is a detailed description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White crystalline solid
-Melting point: 78-80 degrees Celsius
-Boiling point: 335 degrees Celsius
-Density: 1.5g/cm³
-Solubility: Soluble in ethanol, ether, chloroform and benzene and other organic solvents, slightly soluble in water.
Use:
3 ',5'-dichloro-2 '-hydroxyacetophenone has a variety of uses in chemical synthesis, including:
-As an important reagent in scientific research, it is used in organic synthesis reaction.
-In the field of medicine, it is used as a raw material for the synthesis of certain drugs.
-Due to its special aroma, it can also be used for the synthesis of flavors and spices.
Method:
3 ',5'-dichloro-2 '-hydroxyacetophenone can be synthesized by the following steps:
1. Acetophenone is reacted with chlorine in the presence of sodium hydroxide to obtain 2 '-chloroacetophenone.
2.2.2 '-Hydroxyacetophenone is obtained by reacting 2'-chloroacetophenone with ferrous oxide.
3. Finally, on the basis of 2 '-hydroxyacetophenone, chlorine atoms at 3' and 5 'positions are introduced by chlorination reaction to obtain the final product 3',5 '-dichloro-2'-hydroxyacetophenone.
Safety Information:
3 ',5'-dichloro-2 '-hydroxyacetophenone is an organic compound. The following safety precautions should be paid attention to when using it:
-Avoid contact with skin and eyes. Wear appropriate protective gloves, goggles and laboratory coats when using.
-During operation and storage, it is necessary to maintain a well-ventilated environment and avoid inhaling its vapor or dust.
-Avoid contact with strong oxidants and strong acids. Avoid open flames, heat and sparks.
-Do not eat and avoid entering the mouth by mistake. If you accidentally enter, please seek medical attention in time.
Nature:
-Appearance: White crystalline solid
-Melting point: 78-80 degrees Celsius
-Boiling point: 335 degrees Celsius
-Density: 1.5g/cm³
-Solubility: Soluble in ethanol, ether, chloroform and benzene and other organic solvents, slightly soluble in water.
Use:
3 ',5'-dichloro-2 '-hydroxyacetophenone has a variety of uses in chemical synthesis, including:
-As an important reagent in scientific research, it is used in organic synthesis reaction.
-In the field of medicine, it is used as a raw material for the synthesis of certain drugs.
-Due to its special aroma, it can also be used for the synthesis of flavors and spices.
Method:
3 ',5'-dichloro-2 '-hydroxyacetophenone can be synthesized by the following steps:
1. Acetophenone is reacted with chlorine in the presence of sodium hydroxide to obtain 2 '-chloroacetophenone.
2.2.2 '-Hydroxyacetophenone is obtained by reacting 2'-chloroacetophenone with ferrous oxide.
3. Finally, on the basis of 2 '-hydroxyacetophenone, chlorine atoms at 3' and 5 'positions are introduced by chlorination reaction to obtain the final product 3',5 '-dichloro-2'-hydroxyacetophenone.
Safety Information:
3 ',5'-dichloro-2 '-hydroxyacetophenone is an organic compound. The following safety precautions should be paid attention to when using it:
-Avoid contact with skin and eyes. Wear appropriate protective gloves, goggles and laboratory coats when using.
-During operation and storage, it is necessary to maintain a well-ventilated environment and avoid inhaling its vapor or dust.
-Avoid contact with strong oxidants and strong acids. Avoid open flames, heat and sparks.
-Do not eat and avoid entering the mouth by mistake. If you accidentally enter, please seek medical attention in time.
Last Update：2024-04-09 21:04:16
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