399-74-6
2-Chloro-6-fluorobenzothiazole
CAS: 399-74-6
Molecular Formula: C7H3ClFNS
399-74-6 - Names and Identifiers
399-74-6 - Physico-chemical Properties
| Molecular Formula | C7H3ClFNS |
| Molar Mass | 187.62 |
| Density | 1.532±0.06 g/cm3(Predicted) |
| Melting Point | 91-95 °C |
| Boling Point | 253.0±13.0 °C(Predicted) |
| Flash Point | 106.8°C |
| Vapor Presure | 0.0299mmHg at 25°C |
| Appearance | Bright yellow powder |
| pKa | -0.39±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.665 |
| MDL | MFCD07783786 |
399-74-6 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29342000 |
399-74-6 - Introduction
It is an organic compound with the chemical formula C7H3ClFNS. It has a colorless to pale yellow crystalline solid or powder form. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless to light yellow crystalline solid or powder;
-Molecular weight: 191.63g/mol;
-Melting point: 82-84°C;
-Boiling point: 280°C (expected);
-Solubility: Soluble in ethanol, dichloromethane and chloroform.
Use:
-can be used as an important intermediate in organic synthesis;
-It is widely used in the preparation of different types of pharmaceutical compounds, such as anti-cancer drugs, antibacterial drugs and heterocyclic compounds.
Preparation Method:
The preparation method of the benzylamine group is mainly realized by the elimination and substitution reaction of the benzylamine group. The general steps are as follows:
1. reacting 2-chloro-6-fluorophenol with carbon disulfide in an organic solvent to generate a disulfide intermediate;
2. under the catalysis of the base, benzylamine is added to the above intermediate, and the elimination reaction occurs to generate the target product.
Safety Information:
-It is irritating and should avoid direct contact with skin and eyes;
-During use, good ventilation conditions should be maintained to avoid inhalation of gas;
-When storing, should be stored in a dry, cool place, away from fire and oxidant.
Nature:
-Appearance: Colorless to light yellow crystalline solid or powder;
-Molecular weight: 191.63g/mol;
-Melting point: 82-84°C;
-Boiling point: 280°C (expected);
-Solubility: Soluble in ethanol, dichloromethane and chloroform.
Use:
-can be used as an important intermediate in organic synthesis;
-It is widely used in the preparation of different types of pharmaceutical compounds, such as anti-cancer drugs, antibacterial drugs and heterocyclic compounds.
Preparation Method:
The preparation method of the benzylamine group is mainly realized by the elimination and substitution reaction of the benzylamine group. The general steps are as follows:
1. reacting 2-chloro-6-fluorophenol with carbon disulfide in an organic solvent to generate a disulfide intermediate;
2. under the catalysis of the base, benzylamine is added to the above intermediate, and the elimination reaction occurs to generate the target product.
Safety Information:
-It is irritating and should avoid direct contact with skin and eyes;
-During use, good ventilation conditions should be maintained to avoid inhalation of gas;
-When storing, should be stored in a dry, cool place, away from fire and oxidant.
Last Update：2024-04-09 02:00:45
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