55837-20-2
Halofuginone
CAS: 55837-20-2
Molecular Formula: C16H17BrClN3O3
55837-20-2 - Names and Identifiers
55837-20-2 - Physico-chemical Properties
| Molecular Formula | C16H17BrClN3O3 |
| Molar Mass | 414.68 |
| Density | 1.73±0.1 g/cm3(Predicted) |
| Melting Point | >150°C dec. |
| Boling Point | 595.8±60.0 °C(Predicted) |
| Flash Point | 314.116°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 14.61±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.712 |
| Physical and Chemical Properties | Rat oral LD5025mg/kg; But toxic to ducks and geese, 3 mg/kg will lead to their death. |
55837-20-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.411 ml | 12.057 ml | 24.115 ml |
| 5 mM | 0.482 ml | 2.411 ml | 4.823 ml |
| 10 mM | 0.241 ml | 1.206 ml | 2.411 ml |
| 5 mM | 0.048 ml | 0.241 ml | 0.482 ml |
Last Update：2024-01-02 23:10:35
55837-20-2 - Reference Information
| pharmacological effects | halofuginone is a relatively new broad-spectrum anti-coccidiosis drug with small dosage, and other anti-coccidial drugs without cross-resistance and other advantages. This product has obvious inhibitory and killing effect on early reproductive spores of coccidia and the first and second generation merozoites, and can control the discharge of oocysts and reduce the possibility of re-infection. The peak period was 2-3 days after infection. This product has a strong inhibitory effect on 6 Kinds of Eimeria in chicken and 2 kinds of Eimeria in Turkey, and also has an inhibitory effect on rabbit Eimeria. Its Anticoccidial activity is higher than that of Polyether antibiotics. It is also effective against mutton sporozoite and bovine Taylor pear worm. Halofuginone 1~2 mg/kg feed concentration on the chicken tender, toxic, giant Eimeria has good effect; 3 mg/kg feed concentration can prevent the stack, eimeria brucei and Eimeria tenella of Turkey, Eimeria adeno, peafowl Eimeria oocysts. Halofuginone is still effective against coccidia resistant to chloropyridine and quinoxalines. |
| Use | halofuginone has high coccidiocidal activity and is not easy to produce drug resistance. As an anticoccidial drug, it can be used for chicken feed, the dosage is 3G/t, the egg production period is disabled, and the withdrawal period is 5 days. This product is similar to the quinazoline alkaloid of Changshan, a traditional Chinese medicine for malaria. Halofuginone has strong coccidicidal activity, which is highly effective in killing coccidia oocysts. It has the characteristics of broad spectrum, high efficiency, low toxicity, and is not easy to produce drug resistance, and is widely used in the poultry industry. |
| production method | 3-bromo-4-chloro-6-carboxyaniline as raw material, 7-bromo-6-chloro-4 [3H] quinazolinone was cyclically synthesized with formamide in dimethylformamide under reflux for 16h, followed by reaction with 3-methoxy-2-(γ-bromoacetonyl) halofuginone was obtained by condensation of piperidine. The alkaloids extracted from the Chinese herbal medicine Changshan were chemically synthesized. 7-bromo-6-chloro-4-3h-quinazolinone was synthesized with 3-bromo-4-chloro-6-carboxyaniline as raw material, and then refluxed with formamide in dimethylformamide for 16H. It is obtained by condensation with a hydrogen bromide solution of 3-methoxy-2-(γ-bromoacetonyl) piperidine. Intermediate 3-methoxy-2-(γ-bromoacetonyl) piperidine can be obtained by bromination of 3-methoxy-2-acetonyl piperidine at room temperature: |
Last Update：2024-04-09 21:04:16
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