66493-39-8
4-(boc-amino)benzoic acid
CAS: 66493-39-8
Molecular Formula: C12H15NO4
66493-39-8 - Names and Identifiers
| Name | 4-(boc-amino)benzoic acid |
| Synonyms | BOC-4-ABZ-OH Boc-4-Abz-OH RARECHEM EM WB 0012 N-Boc-4-aminobenzoic N-BOC-4-AMINOBENZOIC ACID 4-(boc-amino)benzoic acid (Tert-Butoxy)Carbonyl 4-Abz-OH (1R)-1-(biphenyl-4-yl)ethanaminium (1S)-1-(biphenyl-4-yl)ethanaminium Boc-4-Abz-OH(Boc-4-aMinobenzoic Acid) 4-[(tert-butoxycarbonyl)amino]benzoate 4-[(tert-butoxycarbonyl)amino]benzoic acid N-ALPHA-T-BUTOXYCARBONYL-P-AMINOBENZOIC ACID N-ALPHA-T-BUTOXYCARBONYL-4-AMINO-BENZOIC ACID |
| CAS | 66493-39-8 |
| EINECS | 676-774-4 |
| InChI | InChI=1/C12H15NO4/c1-12(2,3)17-11(16)13-9-6-4-8(5-7-9)10(14)15/h4-7H,1-3H3,(H,13,16)(H,14,15)/p-1 |
66493-39-8 - Physico-chemical Properties
| Molecular Formula | C12H15NO4 |
| Molar Mass | 237.25 |
| Density | 1.242±0.06 g/cm3(Predicted) |
| Melting Point | ~200°C (dec.) |
| Boling Point | 336.2±25.0 °C(Predicted) |
| Flash Point | 157.1°C |
| Vapor Presure | 4.48E-05mmHg at 25°C |
| Appearance | Powder |
| Color | Beige |
| BRN | 2115614 |
| pKa | 4.33±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| MDL | MFCD00037428 |
66493-39-8 - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29242990 |
| Hazard Class | IRRITANT |
66493-39-8 - Introduction
4-(boc-amino)benzoic acid, also known as 4-(boc-amino)benzoic acid, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 4-(boc-amino)benzoic acid is a colorless crystalline or white solid.
-Solubility: Soluble in organic solvents (such as alcohols, chlorinated hydrocarbons and esters), slightly soluble in water.
Use:
-Chemical synthesis: 4-(boc-amino)benzoic acid is an important intermediate in organic synthesis and is often used to synthesize drugs and other active compounds.
-Protecting group: Its N-tert-butoxycarbonyl (BOC) function is often used to protect the amino group in amino compounds.
Preparation Method:
The preparation of 4-(boc-amino)benzoic acid can be carried out by the following steps:
1.4-amino benzoic acid reacts with tert-butyl carbonate to generate tert-butyl 4-(boc-amino)benzoic acid.
2. add hydrolysis reaction under alkaline conditions to generate the target product 4-(boc-amino)benzoic acid.
Safety Information:
- 4-(boc-amino)benzoic acid is generally a low-toxic compound under normal operation.
-However, it is still necessary to comply with laboratory safety practices during operation, including the correct use of personal protective equipment (such as laboratory gloves, protective glasses and laboratory coats).
-Avoid contact with skin, eyes and mucous membranes. In case of contact, rinse immediately with plenty of water and seek medical help.
-In addition, it should be stored in a dry, well-ventilated place, away from heat sources and open flames.
Nature:
-Appearance: 4-(boc-amino)benzoic acid is a colorless crystalline or white solid.
-Solubility: Soluble in organic solvents (such as alcohols, chlorinated hydrocarbons and esters), slightly soluble in water.
Use:
-Chemical synthesis: 4-(boc-amino)benzoic acid is an important intermediate in organic synthesis and is often used to synthesize drugs and other active compounds.
-Protecting group: Its N-tert-butoxycarbonyl (BOC) function is often used to protect the amino group in amino compounds.
Preparation Method:
The preparation of 4-(boc-amino)benzoic acid can be carried out by the following steps:
1.4-amino benzoic acid reacts with tert-butyl carbonate to generate tert-butyl 4-(boc-amino)benzoic acid.
2. add hydrolysis reaction under alkaline conditions to generate the target product 4-(boc-amino)benzoic acid.
Safety Information:
- 4-(boc-amino)benzoic acid is generally a low-toxic compound under normal operation.
-However, it is still necessary to comply with laboratory safety practices during operation, including the correct use of personal protective equipment (such as laboratory gloves, protective glasses and laboratory coats).
-Avoid contact with skin, eyes and mucous membranes. In case of contact, rinse immediately with plenty of water and seek medical help.
-In addition, it should be stored in a dry, well-ventilated place, away from heat sources and open flames.
Last Update：2024-04-09 20:52:54
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