7327-87-9
Dihydralazine Sulfate
CAS: 7327-87-9
Molecular Formula: C8H12N6O4S
7327-87-9 - Names and Identifiers
| Name | Dihydralazine Sulfate |
| Synonyms | Nepresol depressan Depressan CCRIS 5386 Hydralazine Hydralazine sulfate Dihydralazine Sulfate DIHYDRALAZINE SULFATE DIHYDRALAZINE SULPHATE Dihydralazine sulphate Sulfate de dihydralazine DIHYDRALAZINE SULFATE HYDRATE 1,4-dihydrazinophthalazinesulfate Sulfate de dihydralazine [French] 1,4-Dihydrazinophthalazine sulfate 1,4-Dihydrazinophthalazine hydrogen sulfate (4-hydrazinylphthalazin-1-yl)hydrazine,sulfuric acid |
| CAS | 7327-87-9 |
| EINECS | 230-808-0 |
| InChI | InChI=1/C8H10N6.H2O4S/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7;1-5(2,3)4/h1-4H,9-10H2,(H,11,13)(H,12,14);(H2,1,2,3,4) |
7327-87-9 - Physico-chemical Properties
| Molecular Formula | C8H12N6O4S |
| Molar Mass | 288.28 |
| Melting Point | >235°C (subl.) |
| Boling Point | 648.3°C at 760 mmHg |
| Flash Point | 345.9°C |
| Solubility | DMSO: soluble1mg/mL |
| Vapor Presure | 1.09E-16mmHg at 25°C |
| Appearance | powder |
| Color | Off-White to Pale Yellow |
| Storage Condition | Inert atmosphere,Room Temperature |
| Use | For content determination |
7327-87-9 - Risk and Safety
| WGK Germany | 3 |
7327-87-9 - Reference Information
| drug interaction | 1. Heart symptoms are palpitations, tachycardia, and even induce angina, so patients with coronary atherosclerosis are not used, and beta-blockers can avoid these side effects. 2. Long-term use of large doses (more than Arthralgia mg daily) can cause systemic lupus erythematosus-like syndrome, is an autoimmune reaction, manifested as Fever, myalgia, arthritis,, serous exudate, lupus-like rash, spleen and lymph gland enlargement, anemia, neutropenia, etc. About half of the patients had antinuclear antibodies in blood, which could be cured after drug withdrawal, but the duration of rheumatoid symptoms may be longer, to the adrenal cortex hormone can accelerate the elimination of symptoms. But too much medication can also cause death, should pay attention. The daily dosage is below 200mg, this kind of adverse reaction rarely occurs, the blood concentration of slow acetylation type is about twice that of fast acetylation type, and it is easy to cause lupus erythematosus like Syndrome. |
| biological activity | Dihydralazine sulphate (Nepresol, Depressan, 1, 4-didrazinohtalazine, Hydralazine) is a dihydralazine-l, derivatives of 4-phthalazine, used as antihypertensive agents. |
| Use | for the treatment of hypertension or heart failure |
Last Update：2024-04-10 22:29:15
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