82385-42-0
o-Benzoic sulfimide sodium salt hydrate
CAS: 82385-42-0
Molecular Formula: C7H8NNaO5S
82385-42-0 - Names and Identifiers
| Name | o-Benzoic sulfimide sodium salt hydrate |
| Synonyms | SODIUM SACCHARIN SOLUBLE SACCHARIN SODIUM SACCHARIN, DIHYDRATE SOLUBLE SACCHARIN, DIHYDRATE Saccharin sodium salt hydrate Saccharin, sodium salt hydrate SACCHARIN SODIUM SALT DIHYDRATE O-SULFOBENZIMIDE SODIUM SALT DIHYDRATE o-Benzoic sulfimide sodium salt hydrate O-BENZOIC SULFIMIDE SODIUM SALT DIHYDRATE O-BENZOIC ACID SULFIMIDE SODIUM SALT DIHYDRATE 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt, hydrate |
| CAS | 82385-42-0 |
| EINECS | 617-325-4 |
| InChI | InChI=1/C7H5NO3S.Na.H2O/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;;/h1-4H,(H,8,9);;1H2/q;+1;/p-1 |
82385-42-0 - Physico-chemical Properties
| Molecular Formula | C7H8NNaO5S |
| Molar Mass | 241.2 |
| Melting Point | >300°C |
| Boling Point | 438.9°C at 760 mmHg |
| Flash Point | 219.3°C |
| Water Solubility | Soluble in water. |
| Solubility | H2O: 1M at20°C, clear, colorless |
| Vapor Presure | 1.77E-08mmHg at 25°C |
| Appearance | Crystals or Crystalline Powder |
| Color | Colorless to white |
| Merck | 14,8312 |
| BRN | 3599229 |
| Storage Condition | room temp |
| Sensitive | Sensitive to light |
| MDL | MFCD00149605 |
| Physical and Chemical Properties | White Diamond Crystal or crystalline powder, odorless, micro-aromatic gas, a strong sweet taste, after a slightly bitter taste, sweetness of sucrose 300~500 times. The melting point was 226-231 °c. Soluble in water (20 C 99.8g, 50 C 186.8g, 95 C 328.3g), soluble in ethanol (1g/50ml). In the air slowly weathering, about half of the loss of crystal water and become white powder. Mice were injected intraperitoneally with LD5017500mg/kg, rats with oral MNL 500mg/kg,ADI 0~5 mg/kg(FAO/WHO,1994). |
82385-42-0 - Risk and Safety
| WGK Germany | 2 |
| RTECS | DE4550000 |
| TSCA | Yes |
| HS Code | 29251100 |
82385-42-0 - Reference
| Reference Show more | 1. Tu, Yixuan, Shoulei Yan, and Jie Li. "Impact of harvesting time on the chemical composition and quality of fresh lotus seeds." Horticulture, Environment, and Biotechnology 61.4 (2020): 735-744. |
82385-42-0 - Introduction
Easily soluble in water, slightly soluble in ethanol. No odor, sweet and bitter. Sweetness = 300 × sucrose
Last Update：2022-10-16 17:29:09
82385-42-0 - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | sodium saccharin is a commonly used synthetic sweetener. In the human body is not absorbed, does not produce heat. Can be used for plum and tangerine peel, the maximum use of 5.0g/kg; In the seeds of the maximum use of 1.2g/kg; In beverages, wine, ice cream, ice cream, popsicles, pickles, compound seasoning, the maximum dosage of 0.15g/kg in candied fruit, cakes, biscuits and bread, juice concentrate according to the concentration of 80%. general reagent used as food sweetener and diagnostic agent mainly used as food sweetener. Saccharin sodium in the body does not decompose, with the urine discharge, do not supply heat, no nutritional value. Used in the food industry and diabetes patients as a sweet diet. It is also used as a diagnostic drug, and is used as an auxiliary brightener in nickel plating. The LD50 in mice was 17500ml/kg. ADI was tentatively scheduled for 0-2.5ml/kg. 300 times sweetness of sucrose |
| production method | is derived from the formation of salts of O-sulfonylbenzimide (I. E., insoluble saccharin). from phthalic anhydride by amination, degradation, esterification, diazotization, replacement, chlorination, cyclization, acid precipitation, neutralization and other steps. Preparation of methyl anthranilate phthalic anhydride and ammonia water at 0 ° C. Were sequentially added to the reaction kettle, and sodium hydroxide solution was slowly added dropwise after the temperature was raised to 50 ° C., and then aminated under the conditions of temperature ≤ 70 ° C. And pH 8.5-8.9. Then adjust the Ph = 12~13, in the 65~70 C heat preservation 0.5h degradation, after the completion of the heat preservation to catch chlorine 3.5h. Cool to -10 °c, add -10 °c methanol and sodium hypochlorite solution (not excessive), esterification at 0 °c for 45min, then gradually warm to 30 °c, with the starch potassium iodide test paper test showed colorless reaction. Then, an appropriate amount of 20% sodium bisulfite solution is added, after the liquid solution is diluted, the temperature is raised to above 50 ° C., and then hot water of 80 ° C. Is added, stirred and dissolved, left standing and filtered, and the oil layer is separated to obtain methyl anthranilate. Preparation of methyl benzoate O-sulfonyl chloride the mixed acid is first placed in a diazonium pot, and the mixed solution of methyl anthranilate and sodium nitrite solution is added dropwise at about 10 ℃, and the diazotization temperature is kept below 25 ℃, at the end of the reaction, the starch potassium iodide solution was light green. After completion of diazotization, the temperature was lowered to 10 ℃, copper sulfate was added, dissolved, and SO was introduced. At this time, methyl benzoate O-sulfinate was precipitated. After about 1H, the end point of the reaction should be colorless by using H acid test paper. Then add toluene, at 30~35 deg C through chlorine gas chlorination, with 2% benzidine ethanol solution Test showed dark green as the end point. The mixture was allowed to stand and layered, and the organic layer was a toluene solution of O-sulfonyl chloride methyl benzoate. Preparation of insoluble saccharin water and O-sulfonyl chloride methyl benzoate toluene solution are added to the reaction pot in sequence, ammonia water is added at 10 ~ C, and the reaction is stirred for 15min (the temperature can reach 70 ℃, the pH value is above 9) the end point of cyclization was not immediately yellow when tested with 2% benzidine pyridine solution. After standing, the lower ammonium salt solution was taken, toluene and 30% hydrochloric acid were added, and the pH was lowered to below 1. After acid analysis, the temperature was lowered to 20 ℃, and the toluene layer was washed with water to remove ammonium chloride to obtain saccharin toluene solution. Preparation of soluble saccharin the insoluble saccharin toluene solution was heated to 40 °c, and sodium bicarbonate and water were added to adjust the pH to 3.8-4. After standing, take water layer, add activated carbon to decolorize, filter, adjust pH value to 7, add activated carbon to decolorize once. The filtrate was concentrated under reduced pressure at 70-75 °c, maintained at pH 7, and filtered while hot. The filtrate was cooled, crystallized, filtered and dried to obtain sodium saccharin. |
Last Update：2024-04-10 22:29:15
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