848821-76-1

848821-76-1 - Names and Identifiers

Name	2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-
Synonyms	Bis(3,5-bis(trifluoroMethyl)phenyl)(pyrrolidin-2-yl)Methanol (S)-Bis(3,5-bis(trifluoromethyl)phenyl)(pyrrolidin-2-yl)methanol (S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol (S)-2-{Bis[3,5-bis(trifluoromethyl)phenyl]hydroxymethyl}pyrrolidine 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)- 2-PyrrolidineMethanol, a,a-bis[3,5-bis(trifluoroMethyl)phenyl]-, (2S)- (S)-alpha,alpha-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol
CAS	848821-76-1
InChIKey	ITXPGQOGEYWAKW-INIZCTEOSA-N

848821-76-1 - Physico-chemical Properties

Molecular Formula	C21H15F12NO
Molar Mass	525.33
Density	1.465±0.06 g/cm3(Predicted)
Melting Point	113-117°C
Boling Point	391.8±42.0 °C(Predicted)
pKa	12.26±0.29(Predicted)
Storage Condition	2-8°C

848821-76-1 - Risk and Safety

WGK Germany

848821-76-1 - Introduction

2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-, also known as (2S)-2-propylpyrroline-1-carbinol, is an organic compound with the chemical formula C17H14F6NO.

Nature:
-Appearance: 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-as a white solid.
-Melting point: about 94-97 ℃.
-Solubility: Good solubility in common organic solvents.

Use:
- 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-is a chiral decarboxylation reagent commonly used in organic synthesis as a precursor to the corresponding ketone compound. It can be used to synthesize organic compounds such as chiral ketones and alcohols.

Preparation Method:
The synthesis of 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-can be carried out by the following steps:
1. The reaction of (2S)-2-propylpyrroline with benzo trifluorocarbonic anhydride in the presence of sodium carbonate to form the corresponding ester.
2. The ester reacts with hydrofluoric acid to generate the corresponding acid.
3. The acid is reacted with cyanopropanol to give 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-.

Safety Information:
There is no clear report on the safety information of 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S). However, as an organic compound, its use and handling must comply with general safety practices, such as wearing appropriate protective equipment (e. g. gloves, glasses), handling in a well-ventilated environment, and properly stored to avoid exposure to oxidants or sources of ignition. If necessary, the relevant chemical supplier or professional body should also be consulted for detailed safety information.

Last Update：2024-04-10 22:29:15