89226-75-5
MANIDIPINE DIHYDROCHLORIDE
CAS: 89226-75-5
Molecular Formula: C35H40Cl2N4O6
89226-75-5 - Names and Identifiers
89226-75-5 - Physico-chemical Properties
| Molecular Formula | C35H40Cl2N4O6 |
| Molar Mass | 683.62 |
| Melting Point | 157-163°; mp 174-180°; mp 167-170° |
| Boling Point | 722°C at 760 mmHg |
| Flash Point | 390.4°C |
| Water Solubility | Soluble in DMSO. Slightly soluble in water and ethanol/n |
| Solubility | DMSO 21 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| Vapor Presure | 1.07E-20mmHg at 25°C |
| Appearance | solid |
| Color | White |
| Merck | 14,5743 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| In vitro study | At a sustained potential of − 37 mV, the calcium ion concentration response curve was inhibited by Ca manipine at concentrations above 0.1 nM. Manipine inhibited coronary and renal arteries with pIC50 of 9.3 nM and 9.1 nM, respectively. Manipipine partially inhibits sympathetic activity and inhibits the mean arterial pressure response to infusion of norepinephrine. Manidipin also inhibits aldosterone secretion. Manipipine increases urinary calcium and uric acid. In addition, manidipin, at nanomolar concentrations, is able to effectively regulate gene transcription involved in pro-inflammatory changes in mesangial cells. |
| In vivo study | Manidipine (3 mg/kg and 10 mg/kg, p.o.) dose-dependently reduced systolic blood pressure in three types of hypertensive rats. At a dose of 10 mg/kg, manipipine is able to reduce blood pressure to normal levels from 1 hour to 3 hours after administration; The antihypertensive effect lasts at least 8 hours. When manidipin was administered at 10 μg/kg, the hypotensive effect was significantly enhanced. Manidipin effectively inhibited the calcium ion flux induced by depolarization to 0 mV. However, a low concentration of manipine (1-3 nM) enhanced the flux of calcium ions induced by a -20 mV depolarizing pulse with a resting-state membrane potential of -80 mV. The inhibition of calcium ion flux by manidipin develops slowly and requires 10 minutes for maximum inhibition. |
89226-75-5 - Risk and Safety
| UN IDs | UN 2811 6.1/PG III |
| RTECS | US7975300 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba) |
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