BOC-D-2-fluorophenylalanine
BOC-D-2-fluorophenylalanine
CAS: 114873-10-8
Molecular Formula: C14H18FNO4
BOC-D-2-fluorophenylalanine - Names and Identifiers
| Name | BOC-D-2-fluorophenylalanine |
| Synonyms | Boc-D-2-Fluorophe BOC-D-2-FLUOROPHE BOC-D-Phe(2-F)-OH RARECHEM BK PT 0023 BOC-D-2-fluorophenylalanine BOC-2-fluoro-D-phenylalanine (R)-N-BOC-2-FLUOROPHENYLALANINE tert-Butoxycarbonyl-D-2-fluorophenylalanine tert-Butoxycarbonyl-D-2-fluorophenylalanine N-TERT-BUTOXYCARBONYL-2-FLUOROPHENYL-D-ALANINE N-ALPHA-T-BUTOXYCARBONYL-D-(2-FLUOROPHENYL)ALANINE N-ALPHA-TERT-BUTYLOXYCARBONYL-D-2-FLUOROPHENYLALANINE (2R)-2-[(tert-butoxycarbonyl)amino]-3-(2-fluorophenyl)propanoate (R)-2-TERT-BUTOXYCARBONYLAMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID |
| CAS | 114873-10-8 |
| InChI | InChI=1/C14H18FNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-6-4-5-7-10(9)15/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/p-1/t11-/m1/s1 |
BOC-D-2-fluorophenylalanine - Physico-chemical Properties
| Molecular Formula | C14H18FNO4 |
| Molar Mass | 283.3 |
| Density | 1.1918 (estimate) |
| Melting Point | 94-98°C |
| Boling Point | 427.3°C at 760 mmHg |
| Specific Rotation(α) | -10 º (c=1,EtOAc) |
| Flash Point | 212.2°C |
| Vapor Presure | 4.61E-08mmHg at 25°C |
| Storage Condition | Sealed in dry,2-8°C |
| Physical and Chemical Properties | Melting point 94°C specific optical rotation -10 ° (c = 1,EtOAc) |
BOC-D-2-fluorophenylalanine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29242990 |
| Hazard Note | Irritant/Keep Cold |
BOC-D-2-fluorophenylalanine - Introduction
BOC-D-2-Fluorophenylalanine is an organic compound with the chemical formula C≡CuREH≡FNO₂.
Nature:
BOC-D-2-Fluorophenylalanine is a white crystalline solid with a high melting and boiling point. It is almost insoluble in water at normal temperature, but soluble in organic solvents such as methanol, ethanol, dichloromethane, etc. It is a chiral molecule with two stereoisomers (D-form and L-form), the D-form being commonly used.
Use:
BOC-D-2-Fluorophenylalanine has important applications in medicinal chemistry. As a derivative of natural amino acids, it is often used in the study of synthetic peptide drugs and bioactive molecules. It can be used as a protective group to protect the amino group during polypeptide synthesis and prevent unnecessary reactions. In addition, it can also be used as a functional monomer for colloidal materials to control the size and structure of nanoparticles.
Method:
BOC-D-2-fluorophenylalanine is generally synthesized by a synthetic method. A common preparation method is to introduce the BOC protecting group by reacting D-2-fluorophenylalanine with a t-propyldimethylsilyl (BOC) chlorinating agent. The reaction is usually carried out at room temperature and under basic conditions.
Safety Information:
BOC-D-2-Fluorophenylalanine is generally relatively safe under normal conditions of use. However, as a chemical, it is still potentially dangerous. Appropriate safe practices should be followed when handling the substance. Direct contact with the skin or inhalation of its dust or vapor may cause irritation or allergic reactions. Therefore, appropriate personal protective equipment such as lab gloves, safety glasses and breathing masks should be worn during operation. Avoid exposure to fire and avoid operating in poorly ventilated areas to prevent the inhalation of harmful substances. If inadvertent contact occurs, rinse immediately with plenty of water and seek medical help.
Nature:
BOC-D-2-Fluorophenylalanine is a white crystalline solid with a high melting and boiling point. It is almost insoluble in water at normal temperature, but soluble in organic solvents such as methanol, ethanol, dichloromethane, etc. It is a chiral molecule with two stereoisomers (D-form and L-form), the D-form being commonly used.
Use:
BOC-D-2-Fluorophenylalanine has important applications in medicinal chemistry. As a derivative of natural amino acids, it is often used in the study of synthetic peptide drugs and bioactive molecules. It can be used as a protective group to protect the amino group during polypeptide synthesis and prevent unnecessary reactions. In addition, it can also be used as a functional monomer for colloidal materials to control the size and structure of nanoparticles.
Method:
BOC-D-2-fluorophenylalanine is generally synthesized by a synthetic method. A common preparation method is to introduce the BOC protecting group by reacting D-2-fluorophenylalanine with a t-propyldimethylsilyl (BOC) chlorinating agent. The reaction is usually carried out at room temperature and under basic conditions.
Safety Information:
BOC-D-2-Fluorophenylalanine is generally relatively safe under normal conditions of use. However, as a chemical, it is still potentially dangerous. Appropriate safe practices should be followed when handling the substance. Direct contact with the skin or inhalation of its dust or vapor may cause irritation or allergic reactions. Therefore, appropriate personal protective equipment such as lab gloves, safety glasses and breathing masks should be worn during operation. Avoid exposure to fire and avoid operating in poorly ventilated areas to prevent the inhalation of harmful substances. If inadvertent contact occurs, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 20:52:54
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View History
BOC-D-2-fluorophenylalanine
76801-85-9
4513-93-3
IRP-69
2976-75-2
LB-100
tetrachlorocarbon
AM-2394
C.I. 73200
Halometasone
76801-85-9
4513-93-3
IRP-69
2976-75-2
LB-100
tetrachlorocarbon
AM-2394
C.I. 73200
Halometasone