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LGD-4033

LGD-4033

CAS: 1165910-22-4

Molecular Formula: C14H12F6N2O

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LGD-4033 - Names and Identifiers

Name LGD-4033
Synonyms LGD-4033
LIGANDROL
POWDER LGD-4033 LIGANDROL
LIGANDROL (LGD-4033, VK-5211)
lgd 4033 sarms powder lgd-4033 ligandrol
4-((R)-2-((R)-2,2,2-Trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoroMethyl)benzonitrile
4-[(2R)-2-[(1R)-2,2,2-Trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)benzonitrile
4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
4-((R)-2-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoroMethyl)benzonitrile(LGD-4033)
CAS 1165910-22-4
EINECS 1806241-263-5

LGD-4033 - Physico-chemical Properties

Molecular FormulaC14H12F6N2O
Molar Mass338.25
Density1.45±0.1 g/cm3(Predicted)
Melting Point108 - 111°C
Boling Point439.9±45.0 °C(Predicted)
Solubility Acetone (Slightly), Chloroform (Slightly, Heated), Methanol (Slightly)
AppearanceA crystalline solid
ColorWhite to Pale Beige
pKa12.06±0.20(Predicted)
Storage ConditionHygroscopic, -20°C Freezer, Under inert atmosphere
StabilityHygroscopic
In vivo studyIn animal models, LGD-4033 has anabolic activity in muscle, suppressive resorption and anabolic activity in bone, and is more selective in muscle than in prostate. At the concentrations tested, LGD-4033 was safe and well-tolerated, with a long elimination half-life of about 24-36 hours and a linear pharmacokinetics profile.

LGD-4033 - Reference Information

use LGD-4033 is a non-steroidal oral, selective androgen receptor modulator in healthy young people
biological activity Ligandrol (LGD-4033, VK-5211) is a new non-steroidal, orally selective androgen receptor modulator with high affinity (Kd is about 1 nM) and high selectivity for androgen receptors.
TargetValue
Androgen Receptor (Cell-free assay) 1 nM(Ki)
Last Update:2024-04-10 22:29:15
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