dansylcadaverine
dansylcadaverine
CAS: 10121-91-2
Molecular Formula: C17H25N3O2S
dansylcadaverine - Names and Identifiers
| Name | dansylcadaverine |
| Synonyms | 5- Einecs 233-326-9 dansylcadaverine N-(Dimethyl-amino-naphtha-lene-sulfonyl)-1 N-(5-Aminopentyl)-5-(dimethylamino)-1-naphthalenesulfonamide 1-Naphthalenesulfonamide, N-(5-aminopentyl)-5-(dimethylamino)- N-(5-Amino-pentyl)-5-di-methyl-amino-naphtha-lene-1-sulfon-amide Dansylcadaverine [N-(5-AMinopentyl)-5-diMethylaMinonaphthalen-1-sulfonaMide] Monodansyl cadaverine, N-(5-Aminopentyl)-5-dimethylaminonaphthalene-1-sulfonamide, N-(Dimethylaminonaphthalenesulfonyl)-1,5-pentanediamine |
| CAS | 10121-91-2 |
| EINECS | 233-326-9 |
| InChI | InChI=1/C18H27N3O2S/c1-21(2)17-11-7-10-16-15(17)9-8-12-18(16)24(22,23)20-14-6-4-3-5-13-19/h7-12,20H,3-6,13-14,19H2,1-2H3 |
dansylcadaverine - Physico-chemical Properties
| Molecular Formula | C17H25N3O2S |
| Molar Mass | 335.46 |
| Density | 1.190±0.06 g/cm3(Predicted) |
| Melting Point | 137-140°C |
| Boling Point | 505.5±60.0 °C(Predicted) |
| Flash Point | 265.7°C |
| Solubility | 10 mg/mL Methanol |
| Vapor Presure | 9.54E-11mmHg at 25°C |
| Appearance | powder |
| Color | Yellow to yellowish green |
| Maximum wavelength(λmax) | ['335 nm'] |
| BRN | 2951070 |
| pKa | 11.96±0.50(Predicted) |
| Storage Condition | −20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month. |
| Refractive Index | 1.594 |
| MDL | MFCD00042704 |
| Use | A fluorescent amine probe |
| In vitro study | The inhibitory activity of dansylcadaverine reflects its ability to serve as a substrate for transglutaminases and to block competitively the crosslinking of fibrin molecules. Dansylcadaverine, a cationic fluorescent probe binds to bacterial lipopolysaccharide and lipid A, and is displaced competitively by other compounds which possess affinity toward endotoxins. |
dansylcadaverine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-23 |
dansylcadaverine - Reference Information
| biological field application | Measuring cardiac autophagic flux; treating cataract,fibrosis,Parkinson's disease,peritoneal ovarian tumor dissemination,respiratory diseases,lung diseases,Huntington's disease,spinobulbar atrophy,spinocerebellar ataxia,denta |
| Biological activity | Dansylcadaverine (Monodansyl cadaverine) is a self-fluorescent compound used to label autophagy vacuoles. Dansylcadaverine is a high affinity substrate for transglutaminase and can block receptor-mediated endocytosis of various ligands. |
Last Update：2024-04-09 02:00:05
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