(-)-表没食子儿茶素没食子酸酯

性质

淡黄色至茶褐色略带茶叶香味的水溶液，脱水后为灰白色粉状固体或结晶，具涩味。略吸潮，易溶于水、乙醇、乙酸乙酯等极性较强的溶剂，微溶于油脂等弱极性溶剂。本身具有弱酸性，其水溶液pH值约为3～4。耐热及耐酸性较好，在pH2～7范围内稳定，耐光及耐碱性差，在pH>8或光照下易氧化聚合。对真菌、酵母、乳酸菌及醋酸菌均无抑制作用，但可有效地抑制引起龋齿的口腔变异
链球菌。此外，茶多酚具有抗氧化、抗癌变、清除自由基、降血压与降胆固醇等生物学功能。

制法

从茶叶中提取茶多酚的方法主要有沉淀分离法、吸附分离法、有机溶剂提取法、低温纯化酶提取法、盐析法等，新发展的方法有超临界溶剂提取法等。这里介绍最常用的钙盐沉淀分离法。茶叶粉碎后在萃取釜中用80℃热水浸泡30min，过滤，再用少量沸水洗涤滤饼，将洗涤液与滤液合并，滤饼干燥后可提咖啡因等其他成分。滤液倒入沉淀容器中，按滤液：石灰水：食盐水-1:6:5左右的比例加入饱和石灰水和饱和石灰水和饱和食盐水，充分搅拌后静置30 min，过滤。再将滤饼置于酸化器中，加入0. 5%～0.8%的H2 S04，调节pH一7.1～7.2，然后用乙酸或柠檬酸调pH值至7．O，充分搅拌，然后静置30min，过滤，水洗，滤液经喷雾干燥可得成品。

用途

可用作食品抗氧化剂和防腐剂，广泛用于动植物油脂、水产品、饮料、糖果、乳制品、油炸食品、调味品、化妆品及功能性食品的抗氧化，还具有消除异味，防腐保鲜等作用。如果使用对象为脂
溶性，可将茶多酚溶于95%食品乙醇配成溶液后加入。若使用对象为水溶性，可直接将茶多酚加入或溶于水后加入，对肉制品可直接用0. 05%茶多酚溶液浸渍或喷涂。

中文名	(-)-表没食子儿茶素没食子酸酯
英文名	(-)-epigallocatechin gallate
别名	茶多酚绿茶提取物 (-)-儿茶素酸酯表没食子儿茶精3-没食子酸酯 (-)-表没食子儿茶素没食子酸酯 (EGCG) 表没食子儿茶素没食子酸酯 EGCG(表没食子酸儿茶素没食子酸酯) (-)-表没食子儿茶素没食子酸酯水合物表没食子儿茶素没食子酸酯 (EGCG) 绿茶提取液
英文别名	EGCG Green Tea TEA CATECHIN Green Tea P.E Tea polyphenol Tea Polyphenols Green Tea Extract Green tee extract Green Tea Extract Powder L-Epigallocatechin Gallate (-)-epigallocatechin gallate Green tea extract Polyphenols Epigallocatechin-3-Monogallate (-)-Epigallocatechin Gallate-d6 (-)-Epigallocatechin-3-O-gallate (20 mg) (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate (-)-CIS-2-(3,4,5-TRIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3 ,5,7-TRIOL 3-GALLATE(-)-CIS-3,3',4',5,5',7-HEXAHYDROXY-FLAVANE-3-GALLATE
CAS	989-51-5 84650-60-2
EINECS	479-560-7
化学式	C22H18O11
分子量	458.37
InChI	InChI=1/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1
InChIKey	WMBWREPUVVBILR-WIYYLYMNSA-N
密度	1.90±0.1 g/cm3(Predicted)
熔点	222-224°C
沸点	909.1±65.0 °C(Predicted)
比旋光度	D -185 ±2°(ethanol)
闪点	320°C
水溶性	Soluble in ethanol, dimethyl formamide, water.
蒸汽压	3.71E-35mmHg at 25°C
溶解度	H2O: ≥ 5mg/ml，澄清
折射率	-175.5 ° (C=1, EtOH)
酸度系数	7.75±0.25(Predicted)
存储条件	2-8°C
稳定性	稳定，但可能对光敏感。与强氧化剂不相容。
外观	整洁
颜色	White to Light Brown
Merck	14,3526
物化性质	白色结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于茶叶Tea。
MDL号	MFCD00075940
体外研究	(-)-Epigallocatechin gallate在健康细胞中具有强效抗氧化作用，并降低氧化损伤，作为抗血管生成和抗肿瘤剂，也是肿瘤细胞对化疗应答的调节剂。(-)-Epigallocatechin gallate具有多种抗肿瘤作用，例如抗增殖，抗血管新生，阻断各种癌细胞转化，细胞周期阻滞和抑制肿瘤转移。(-)-Epigallocatechin gallate通过调节多个肿瘤相关的细胞信号通路（调节关键信号蛋白的表达水平，例如核因子-κB, MAPKs和激活蛋白-1，EGFR，IGF，COX-2）影响肿瘤基因的甲基化和配体与膜受体结合发挥抗肿瘤效果。 (-)-Epigallocatechin gallate具有免疫调节作用。多种类型的免疫细胞在先天的和适应性免疫系统中都会不同程度受到(-)-Epigallocatechin gallate的影响。在这些作用中，对T细胞的显著作用被反复证明，包括T细胞激活，增殖，分化和细胞因子产生。基于患有自身免疫疾病的动物模型的研究报道表明，绿茶/EGCG处理会使动物的病情好转。 (-)-Epigallocatechin gallate具有抗感染活性。(-)-Epigallocatechin gallate的以不同激活模式产生的抗病毒活性在很多种属的病毒中被证实，例如逆转录病毒，正粘病毒科和黄病毒科，还包括重要的人类病原细菌，如人类免疫缺陷病原体，甲型流感病毒和丙型肝炎病毒。
安全术语	24/25 - 避免与皮肤和眼睛接触。
WGK Germany	2
RTECS	KB5200000
FLUKA BRAND F CODES	10-23
海关编号	29339900
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(-)-表没食子儿茶素没食子酸酯 - 性质

可信数据

最后更新：2024-01-02 23:10:35

(-)-表没食子儿茶素没食子酸酯 - 制法

可信数据

最后更新：2022-01-01 11:16:06

(-)-表没食子儿茶素没食子酸酯 - 用途

可信数据

最后更新：2022-01-01 11:16:07

(-)-表没食子儿茶素没食子酸酯 - 简介

(-)-表没食子儿茶素没食子酸酯，也称为(-)-EPiGalloCatechin-3-Gallate (EGCG)，是一种来源于茶叶的天然化合物。

性质：
(-)-表没食子儿茶素没食子酸酯是一种白色结晶性粉末，在室温下稳定。它还具有抗炎、抗肿瘤、抗菌和抑制血小板聚集等生物活性。

用途：它被认为是茶叶中最重要的活性成分之一，可以发挥多种保健作用。它具有抗癌、抗氧化、降低血压、降低血糖、降低胆固醇等作用。

制法：
(-)-表没食子儿茶素没食子酸酯可以通过提取茶叶中的(-)-表没食子儿茶素，然后与没食子酸酯酯化反应制得。具体的制法可根据实际需要进行优化。

安全信息：
(-)-表没食子儿茶素没食子酸酯被广泛认为是安全的，目前没有报道其对人体的有害作用。过量摄入可能对个别人产生一定的不良反应。故适量使用更为安全。特殊人群如孕妇和儿童需要在医生指导下使用。

最后更新：2024-04-09 20:52:54

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