(3B,20B)-3-羟基-11-氧代-齐墩果-12-烯-29-酸
甘草亭酸(18-Beta-Glycyrrhetinic acid)
CAS: 471-53-4
化学式: C30H46O4
| 中文名 | 甘草亭酸 |
| 英文名 | 18-Beta-Glycyrrhetinic acid |
| 别名 | 甘珀酸 甘草次酸 甘草亭酸 beta-甘草亭酸 BETA-甘草次酸 甘草次酸, 来源于甘草 18Β-甘草次酸标准品 18 BETA 甘草次酸 甘草次酸(18-Β-甘草次酸) 3β-羟基-11-氧-12-齐墩果烯-30-酸 (3β,20β)-3-羟基-11-氧代-齐墩果-12-烯-29-酸 (3B,20B)-3-羟基-11-氧代-齐墩果-12-烯-29-酸 |
| 英文别名 | Enoxolone Glycyrrheticacid Glycyrrhetic acid Glycyrrhetinic acid 18B-glycyrrhetinic acid alpha-glycyrrhetinicacid 18-beta-glycyrrheticacid 18beta-Glycyrrhetinic acid 18-Beta-Glycyrrhetinic acid GLYCYRRHETINIC ACID, 18B-(P) Aloe Vera, Freeze Dried Powder 3-Hydroxy-11-oxo-12-oleanen-30-oicacid 3-beta-hydroxy-11-oxoolean-12-en-30-oicacid 3-beta-hydroxy-11-oxo-olean-12-en-30-oicaci 3.beta.-Hydroxy-11-oxo-12-oleanen-30-oicacid (20S)-3β-Hydroxy-11-oxo-5α-olean-12-en-29-oic acid Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3b,20b)- 3-hydroxy-11-oxo-,(3beta,20beta)-olean-12-en-29-oicaci (3beta,5xi,9xi)-3-hydroxy-11-oxoolean-12-en-30-oic acid 3-hydroxy-11-oxo-,(3.beta.,20.beta.)-Olean-12-en-29-oicacid Enoxolone, 3β-Hydroxy-11-oxo-18β,20β-olean-12-en-29-oic acid |
| CAS | 471-53-4 |
| EINECS | 207-444-6 |
| 化学式 | C30H46O4 |
| 分子量 | 470.69 |
| InChI | InChI=1/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21?,22-,23?,26+,27-,28-,29+,30+/m0/s1 |
| 密度 | 0.9967 (rough estimate) |
| 熔点 | 292-295°C(lit.) |
| 沸点 | 492.11°C (rough estimate) |
| 比旋光度 | 165 º (c=1, CHCl3,on dry ba) |
| 闪点 | 323.7°C |
| 水溶性 | SOLUBLE IN ACETIC ACID |
| 蒸汽压 | 10-220Pa at 20-50℃ |
| 溶解度 | 几乎不溶于水，溶于乙醇，微溶于二氯甲烷。 |
| 折射率 | 162 ° (C=1, MeOH) |
| 酸度系数 | pKa 5.56±0.1 (Uncertain) |
| 存储条件 | 2-8°C |
| 外观 | 结晶性粉末 |
| 颜色 | White to off-white |
| Merck | 14,3590 |
| BRN | 2229654 |
| 物化性质 | 由甘草酸-ff两个分子的葡萄糖醛酸组成的苷。白色结晶性粉末，味甜，甜度约为蔗糖的200倍。其甜味与蔗糖等甜味剂不同，入口后要略过片刻才有甜味感，但留存时间长。少量甘草苷与蔗糖并用可少用20%蔗糖而甜度不变。虽无香气，但有增香效能。熔点(分解)220℃。水溶液呈弱酸性，可由酸的作用 |
| MDL号 | MFCD00003706 |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | R22 - 吞食有害。 R36 - 刺激眼睛。 |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 3 |
| RTECS | RK0180000 |
| 海关编号 | 29189900 |
| 上游原料 | 甘草 甘草酸三铵盐 |
| 下游产品 | 硬脂醇甘草亭酸酯 |
| 参考资料 展开查看 | 1. 顾薇 毛春芹 袁晓莉 等. HPLC-ELSD法精确定量大鼠胆汁中牛磺胆酸的方法研究[J]. 生物技术世界 2015 000(011):17-18. 2. 王守云 霍韬光 封聪 等. LC-MS/MS测定小鼠肝脏中甘草次酸含量[J]. 化学研究 2016 27(004):429-432. 3. 封聪 霍韬光 王守云 等. LC-MS/MS测定小鼠肾脏中甘草次酸的含量[J]. 化学研究 2016(3):318-322. 4. 王胜超 张振凌 于文娜 等. 人中黄的HPLC指纹图谱及炮制机理初探[J]. 中药材 2017(05):83-87. 5. 董月柳, 李雪莲, 陈江鹏,等. 多成分环境下甘草次酸肠吸收行为的研究[J]. 中草药, 2017(16). 6. 方莹,张颖花,霍韬光,何俏,侯明山,姜泓,康廷国.微透析-HPLC测定甘草次酸对雄黄染毒小鼠海马细胞外液中Cys和Hcy含量的影响[J].化学研究,2016,27(02):202-205. 7. 王立英, 刘雨萌, 金元宝,等. 甘草次酸对谷氨酸所致PC12细胞损伤的保护作用及其机理[J]. 华西药学杂志, 2013(04):24-27. 8. 王艳蕾, 贾雨涵, 赵嘉涵,等. 甘草次酸对雄黄致小鼠海马突触超微结构损伤的改善作用[J]. 吉林大学学报(医学版), 2019, 045(002):268-272. 9. 盖亚男, 汪琼, 陈剑,等. 盾叶薯蓣4种皂苷含量的LC-MS/MS快速测定法[J]. 现代中药研究与实践, 2017(02):54-56. 10. 王泽 慈小燕 崔涛 魏滋鸿 张洪兵 刘睿 李亚卓 伊秀林 张铁军 谷元 武卫党 刘昌孝.不同药性成分对OAT4、URAT1抑制作用及对急性高尿酸血症小鼠血尿酸水平的影响[J].中草药 2019 50(05):1157-1163. 11. 仲金秋, 曹玉珠, 徐宏江,等. 甘草酸二铵改善ConA致小鼠肝损伤的作用研究[J]. 天然产物研究与开发, 2018, 30(12):60-68. 12. 王胜超 张振凌 刘艳 等. 人中黄炮制前后6种化学成分的含量变化及其质量评价[J]. 中国实验方剂学杂志 2017 023(009):11-16. 13. 程丽娜, 曹世杰, 曲明,等. 甘草主要成分改善L6大鼠成肌细胞胰岛素抵抗的机制[J]. 中国实验方剂学杂志, 2020(4). 14. 纪万里,周泽华,王婷婷,安叡,梁琨,王新宏.基于UPLC-LTQ-Orbitrap-MS方法分析半夏泻心汤化学成分[J].药物分析杂志,2020,40(10):1736-1750. 15. Tao, Y, Huang, S, Yan, J, Cai, B. A reliable LC–MS/MS method for the quantification of five bioactive saponins of crude and processed Bupleurum scorzonerifolium in rat plasma and its application to a pharmacokinetic study. Biomedical Chromatography. 2019; 16. Yi Tao, Dandan Su, Weidong Li, Baochang Cai, Pharmacokinetic comparisons of six components from raw and vinegar-processed Daphne genkwa aqueous extracts following oral administration in rats by employing UHPLC–MS/MS approaches, Journal of Chromatography B, 17. Tao-Guang, H. U. O., et al. "Liver metabonomics study on the protective effect of glycyrrhetinic acid against realgar-induced liver injury." Chinese journal of natural medicines 18.2 (2020): 138-147.https://doi.org/10.1016/S1875-5364(20)30014-5 18. Tao, Yi, et al. "Development and validation of an UHPLC–MS/MS approach for simultaneous quantification of five bioactive saponins in rat plasma: Application to a comparative pharmacokinetic study of aqueous extracts of raw and salt-processed Achyranthes bi 19. 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Journal of Chromatography B 1036 (2016): 33-41.h 23. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 24. [IF=4.36] Taoguang Huo et al."Plasma metabolomics study of the hepatoprotective effect of glycyrrhetinic acid on realgar-induced sub-chronic hepatotoxicity in mice via 1H NMR analysis."J Ethnopharmacol. 2017 Aug;208:36 25. [IF=3.205] Zhuangzhuang Li et al."Simultaneous quantification of fifteen compounds in rat plasma by LC-MS/MS and its application to a pharmacokinetic study of Chaihu-Guizhi decoction."J Chromatogr B. 2019 Jan;1105:15 26. [IF=10.479] Jing Guo et al."Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug."J Adv Res. 2021 Oct;: 27. 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[IF=3.365] Tao Yang et al."Protection function of 18β-glycyrrhetinic acid on rats with high-altitude pulmonary hypertension based on 1H NMR metabonomics technology."Anal Biochem. 2021 Oct;631:114342 32. [IF=3.361] Dan-Ni Feng et al."Green synthesis and characterization of gold nanoparticles and their application for the rapid detection of glycyrrhizin with immunochromatographic strips."Rsc Adv. 2021 Jul;11(39):23851-23859 33. [IF=3] Tao-Guang HUO et al."Liver metabonomics study on the protective effect of glycyrrhetinic acid against realgar-induced liver injury."Chin J Nat Medicines. 2020 Feb;18:138 34. [IF=2.629] Li Tingting et al."Quality Assessment of Licorice Based on Quantitative Analysis of Multicomponents by Single Marker Combined with HPLC Fingerprint."Evid-Based Compl Alt. 2021;2021:8834826 35. [IF=1.902] Yi Tao et al."A reliable LC–MS/MS method for the quantification of five bioactive saponins of crude and processed Bupleurum scorzonerifolium in rat plasma and its application to a pharmacokinetic study."Biomed Chromatogr. 2019 Sep;33(9):e4570 |
(3B,20B)-3-羟基-11-氧代-齐墩果-12-烯-29-酸 - 简介
甘草亭酸，又称苯甲酸，是一种有机化合物。下面是关于甘草亭酸的性质、用途、制法和安全信息的介绍：
性质：
甘草亭酸是一种无色结晶固体，有特殊的芳香气味。它可溶于热水、乙醇、醚等有机溶剂，微溶于冷水。甘草亭酸具有一定的腐蚀性。
用途：
甘草亭酸在化工领域有广泛的应用。在有机合成中，甘草亭酸可以作为重要的反应中间体。
制法：
甘草亭酸一般通过苯甲醇与氧气氧化反应而制得。首先将苯甲醇与氧气通入反应器中，通过催化剂的作用，进行氧化反应，生成甘草亭酸。
安全信息：
甘草亭酸在正常使用条件下一般是安全的。应将甘草亭酸储存在干燥、通风良好的地方，远离火源和氧化剂。在使用时应戴好防护手套、护目镜等个人防护装备，避免吸入其气体。
性质：
甘草亭酸是一种无色结晶固体，有特殊的芳香气味。它可溶于热水、乙醇、醚等有机溶剂，微溶于冷水。甘草亭酸具有一定的腐蚀性。
用途：
甘草亭酸在化工领域有广泛的应用。在有机合成中，甘草亭酸可以作为重要的反应中间体。
制法：
甘草亭酸一般通过苯甲醇与氧气氧化反应而制得。首先将苯甲醇与氧气通入反应器中，通过催化剂的作用，进行氧化反应，生成甘草亭酸。
安全信息：
甘草亭酸在正常使用条件下一般是安全的。应将甘草亭酸储存在干燥、通风良好的地方，远离火源和氧化剂。在使用时应戴好防护手套、护目镜等个人防护装备，避免吸入其气体。
最后更新：2024-04-09 21:11:58
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