108340-60-9
灵芝酸D(Ganoderic acid D)
CAS: 108340-60-9
化学式: C30H42O7
| 中文名 | 灵芝酸D |
| 英文名 | Ganoderic acid D |
| 别名 | 灵芝酸D 灵芝酸D标准品 灵芝酸D对照品, |
| 英文别名 | Ganoderic acid D (7beta)-7-Hydroxy-3,11,15,23-tetraoxolanost-8-en-26-oic acid Lanost-8-en-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β)- |
| CAS | 108340-60-9 |
| 化学式 | C30H42O7 |
| 分子量 | 514.65 |
| 密度 | 1.22±0.1 g/cm3(Predicted) |
| 沸点 | 688.3±55.0 °C(Predicted) |
| 溶解度 | 氯仿，甲醇 |
| 酸度系数 | 4.77±0.23(Predicted) |
| 存储条件 | 2-8℃ |
| 外观 | 白色粉末或结晶 |
| 物化性质 | 白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于多孔菌科灵芝Ganodermalucidum（Leyss.exFr.）Karst．的干燥子实体。 |
| MDL号 | MFCD29049470 |
| 体外研究 | Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC 50 of 17.3 mM. Ganoderic acid D (1-50 μM; 24-72 hours) reduces the cell survival rate in a dose- and time-dependent manner. Ganoderic acid D (10, 50 μM; 24, 48 hours) induces G2/M phase arrest. Ganoderic acid D (10, 50 μM; 24, 48 hours) induces a morphological change typical of apoptosis in HeLa cells. Ganoderic acid D (10 μM; 48 hours) up-regulates 14-3-3E and PRDX3. Cell Viability Assay Cell Line: HeLa human cervical carcinoma cell line (CCL-2) Concentration: 1, 5, 10, 20, 50 μM Incubation Time: 24, 48, 72 hours Result: Reduced the cell survival rate in a dose- and time-dependent manner and had an IC 50 value of 17.3 μM for 48 hours treatment. Cell Cycle Analysis Cell Line: HeLa human cervical carcinoma cell line (CCL-2) Concentration: 10, 50 μM Incubation Time: 24, 48 hours Result: Induced G2/M phase arrest. Displayed a cell cycle profile with an elevated G2/M cell population after 24-h treatment with 10 μM. Apoptosis Analysis Cell Line: HeLa human cervical carcinoma cell line (CCL-2) Concentration: 10, 50 μM Incubation Time: 48 hours Result: Induced a morphological change typical of apoptosis in HeLa cells. Western Blot Analysis Cell Line: HeLa human cervical carcinoma cell line (CCL-2) Concentration: 10 μM Incubation Time: 48 hours Result: Up-regulated 14-3-3E and PRDX3. |
| 参考资料 展开查看 | 1. 沐华, 蔡铭, 徐靖,等. 破壁与去壁灵芝孢子粉的化学成分与抗氧化活性比较[J]. 食品工业科技, 2020, 041(010):32-37,51 2. 范蕾, 陈琴鸣, 陈张金,等. 灵芝一测多评质量控制方法的研究[J]. 中国药师, 2018, v.21(05):76-80. |
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