108340-60-9
Ganoderic acid D
CAS: 108340-60-9
Molecular Formula: C30H42O7
108340-60-9 - Names and Identifiers
| Name | Ganoderic acid D |
| Synonyms | Ganoderic acid D (7beta)-7-Hydroxy-3,11,15,23-tetraoxolanost-8-en-26-oic acid Lanost-8-en-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β)- |
| CAS | 108340-60-9 |
108340-60-9 - Physico-chemical Properties
| Molecular Formula | C30H42O7 |
| Molar Mass | 514.65 |
| Density | 1.22±0.1 g/cm3(Predicted) |
| Boling Point | 688.3±55.0 °C(Predicted) |
| Solubility | Chloroform, methanol |
| Appearance | White powder or crystal |
| pKa | 4.77±0.23(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD29049470 |
| Physical and Chemical Properties | White powder, soluble in methanol, ethanol, DMSO and other organic solvents, comes from Leyss.exFr.)Karst, Ganodermalucidum of Ganoderma lucidum of Polyporaceae. The dry fruit body. |
| In vitro study | Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC 50 of 17.3 mM. Ganoderic acid D (1-50 μM; 24-72 hours) reduces the cell survival rate in a dose- and time-dependent manner. Ganoderic acid D (10, 50 μM; 24, 48 hours) induces G2/M phase arrest. Ganoderic acid D (10, 50 μM; 24, 48 hours) induces a morphological change typical of apoptosis in HeLa cells. Ganoderic acid D (10 μM; 48 hours) up-regulates 14-3-3E and PRDX3. Cell Viability Assay Cell Line: HeLa human cervical carcinoma cell line (CCL-2) Concentration: 1, 5, 10, 20, 50 μM Incubation Time: 24, 48, 72 hours Result: Reduced the cell survival rate in a dose- and time-dependent manner and had an IC 50 value of 17.3 μM for 48 hours treatment. Cell Cycle Analysis Cell Line: HeLa human cervical carcinoma cell line (CCL-2) Concentration: 10, 50 μM Incubation Time: 24, 48 hours Result: Induced G2/M phase arrest. Displayed a cell cycle profile with an elevated G2/M cell population after 24-h treatment with 10 μM. Apoptosis Analysis Cell Line: HeLa human cervical carcinoma cell line (CCL-2) Concentration: 10, 50 μM Incubation Time: 48 hours Result: Induced a morphological change typical of apoptosis in HeLa cells. Western Blot Analysis Cell Line: HeLa human cervical carcinoma cell line (CCL-2) Concentration: 10 μM Incubation Time: 48 hours Result: Up-regulated 14-3-3E and PRDX3. |
108340-60-9 - Reference
| Reference Show more | 1. Muhua, Cai Ming, Xu Jing, et al. Comparison of chemical constituents and antioxidant activities between wall-broken and wall-removed spores of Ganoderma lucidum [J]. Science and Technology of food industry, 2020, 041(010):32-37,51 2. Fan Lei, Chen Qinming, Chen Zhang Jin, et al. Study on quality control method of multiple evaluation of Ganoderma lucidum [J]. China pharmacist, 2018, v.21(05):76-80. |
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Product Name: Ganoderic acid D Visit Supplier Webpage Request for quotationCAS: 108340-60-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Ganoderic acid D Visit Supplier Webpage Request for quotationCAS: 108340-60-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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