120444-71-5_化工百科

中文名	德伦环烷
英文名	DERAMCICLANE
别名	德伦环烷化合物 T10996
英文别名	EGIS-3886 DERAMCICLANE DERAMCLCLANE N,N-Dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]ethanamine N,N-Dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine N,N-dimethyl-2-(((1S,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine N,N-dimethyl-2-[[(1R,3S,4R)-4,7,7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine Ethanamine, N,N-dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]-
CAS	120444-71-5
化学式	C20H31NO
分子量	301.47
密度	1.01±0.1 g/cm3(Predicted)
沸点	375.2±25.0 °C(Predicted)
酸度系数	pKa 9.61±0.03(H2O t=25±0.1 I=0.1(NaCl)) (Uncertain)
存储条件	Room Temprature
体外研究	Deramciclane is a novel anxiolytic agent that binds with high affinity to 5-HT 2A / 2C receptors. The interactions of Deramciclane with the serotonin 5-HT 2C receptor are characterized further using receptor phosphoinositide hydrolysis assays and receptor autoradiography. Deramciclane antagonizes 5-HT 2C receptor mediated 5-HT-stimulated phosphoinositide hydrolysis with an IC 50 value of 168 nM. Deramciclane also decreases basal phosphoinositide hydrolysis by up to 33% (EC 50 = 93 nM) in a physiological system in the choroid plexus, suggesting that Deramciclane possesses inverse agonist properties at this receptor.
体内研究	Deramciclane 3 and 10 mg/kg does not change the dopamine levels significantly at any time point versus the basal level whereas 30 mg/kg of Deramciclane significantly increases the levels at 40-100 min and at 160-240 min (P<0.05). Deramciclane is a putative antiserotonergic compound that reduces 5-HT-induced phosphoinositol hydrolysis and a variety of actions caused by serotonergic agonists. The receptor binding profile of Deramciclane is rather similar to that of ritanserin. Deramciclane has a high affinity for 5-HT 2A and 5-HT 2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT 2C receptors without direct stimulatory agonist effects. Deramciclane has been shown to have anxiolytic-like activity in several animal tests.

120444-71-5 - 简介

德伦环烷，也被称为环顺式四甲基环戊烷或TCH，是一种有机化合物。下面是关于德伦环烷的性质、用途、制法和安全信息的介绍：

性质：
德伦环烷是一种无色至淡黄色的液体，具有特殊的香味。它具有低毒性和低挥发性，不易溶于水，但可溶于有机溶剂。

用途：
德伦环烷在工业上广泛用作溶剂、去污剂和防腐剂。德伦环烷还用于合成其他化合物，如染料、农药和合成橡胶的中间体。

制法：
德伦环烷的制备通常通过环戊烯的四烷基化反应来实现。具体而言，环戊烯与甲基氯化铝等四烷基化试剂反应，得到德伦环烷。

安全信息：
德伦环烷具有低毒性，但仍然应避免吸入或接触皮肤。在操作时应戴上适当的防护手套、保护眼睛和呼吸系统的装备。
德伦环烷易燃，应远离明火和热源，并储存在阴凉、通风良好的地方。
当德伦环烷被意外泄漏时，需要立即采取措施清除泄漏物，并确保适当的通风。

最后更新：2024-04-09 20:52:54

上海麦克林生化科技股份有限公司

现货供应

产品名: Deramciclane 去供应商网站查看询盘
CAS: 120444-71-5
产地: 上海
规格: D884018
价格: 5mg-3326,1mg-1664
库存: 15天内发货
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