中文名 | (E)-Alprenoxime |
英文名 | (E)-Alprenoxime |
别名 | 化合物 T10001 |
英文别名 | CDDD-1815 (E)-Alprenoxime 1-[2-(2-Propenyl)phenoxy]-3-isopropylaminoacetone (E)-oxime 2-Propanone, 1-[(1-methylethyl)amino]-3-[2-(2-propenyl)phenoxy]-, oxime, (E)- (9CI) |
CAS | 125720-84-5 |
化学式 | C15H22N2O2 |
分子量 | 262.34738 |
密度 | 1.02±0.1 g/cm3(Predicted) |
沸点 | 398.7±37.0 °C(Predicted) |
溶解度 | DMSO |
酸度系数 | 11.41±0.10(Predicted) |
存储条件 | -20℃ |
体内研究 | The purpose of the present study is to explore the pharmacological significance of Alprenoxime peripheral /βblocking activity in a non-rodent animal model. Interspecies scaling considerations predict that the doses selected in this study (1 and 5 mg/kg) are pharmacologically comparable or greater than doses used in rodent studies (2 and 6 mg/kg). More importantly, the prolonged ocular antihypertensive effects that are shown with 1% ophthalmic solutions indicate that the i.v. dose tested in the present study is likely to be more than two orders of magnitude greater than probable therapeutic doses. |
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