197250-15-0
GAP26(GAP 26)
CAS: 197250-15-0
化学式: C70H107N19O19S
| 中文名 | GAP26 |
| 英文名 | GAP 26 |
| 别名 | 化合物GAP 26 穿膜肽GAP 26 GAP 26游离态 |
| 英文别名 | VR-13 GAP26 GAP 26 GAP-26 GAP26 43Gap 26, Connexin Mimetic M.W. 1550.78 C70H107N19O19S Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg H-VAL-CYS-TYR-ASP-LYS-SER-PHE-PRO-ILE-SER-HIS-VAL-ARG-OH L-Arginine, L-valyl-L-cysteinyl-L-tyrosyl-L-α-aspartyl-L-lysyl-L-seryl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-seryl-L-histidyl-L-valyl- |
| CAS | 197250-15-0 |
| 化学式 | C70H107N19O19S |
| 分子量 | 1550.78 |
| 密度 | 1.47±0.1 g/cm3(Predicted) |
| 水溶性 | Soluble to 2 mg/ml in water |
| 溶解度 | H2O: 50毫克/毫升 (32.24毫米; 需要超声波) |
| 酸度系数 | 3.31±0.10(Predicted) |
| 存储条件 | Keep in dark place,Inert atmosphere,2-8°C |
| 体外研究 | Gap 26 (0.25 mg/mL, 30 min) reduces the wave size in the three cell lines (RBE4, SV-ARBEC and ECV304). Gap 26 (0.25 mg/mL, 30 min) completely abolishes the InsP3-triggered ATP response and reduced the ATP release to below the control level, indicating that the basal ATP release is also affected. Gap 26 does indeed significantly inhibit our InsP3-triggered intercellular calcium waves, but it did not have any effect on dye coupling through junctional channels as evidenced by the FRAP experiments, despite the fact that connexin 43 was present in the cell lines used. Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC 50 of 28.4 ± 3.4 μM. |
197250-15-0 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.645 ml | 3.224 ml | 6.448 ml |
| 5 mM | 0.129 ml | 0.645 ml | 1.29 ml |
| 10 mM | 0.064 ml | 0.322 ml | 0.645 ml |
| 5 mM | 0.013 ml | 0.064 ml | 0.129 ml |
最后更新：2024-01-02 23:10:35
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