2332897-85-3
Nav1.1 activator 1(Nav1.1 activator 1)
CAS: 2332897-85-3
化学式: C24H23F3N4O
| 中文名 | Nav1.1 activator 1 |
| 英文名 | Nav1.1 activator 1 |
| 别名 | 化合物 T12179 |
| 英文别名 | Nav1.1 activator 1 |
| CAS | 2332897-85-3 |
| 化学式 | C24H23F3N4O |
| 分子量 | 440.46 |
| 体内研究 | Nav1.1 activator 1 (compound 4) is a valuable Na v 1.1 activator for further evaluation of pathophysiological functions of the Nav1.1 channel and has potential for therapeutic treatments of CNS diseases such as Dravet syndrome. Animal Model: Mice. Dosage: 30 mg/kg ( Pharmacokinetic Analysis ). Administration: IP once (Exposure was measured at 1 h after administration). Result: Intraperitoneal administration (30 mg/kg) of compound resulted in sufficient brain exposure (193 ng/g 1 h after administration), which corresponded to 13 nM of free brain concentration comparable to the in vitro potency of the compound. Had a potential use as an in vivo tool to investigate whether this type of Na v 1.1 activator can restore Na v 1.1 functions and modify the disease state in animal models. Could penetrate the blood-brain barrier (BBB) in humans. |
供应商列表
现货供应
产品名: Nav1.1 activator 1 去供应商网站查看 询盘CAS: 2332897-85-3
产地: 中国上海
包装: 5mg
规格: 98%
价格: 3498.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：Nav1.1 activator 1 英文名:Nav1.1 activator 1 CAS:2332897-85-3 规格:98% 产地:中国上海
现货供应
产品名: Nav1.1 activator 1 去供应商网站查看 询盘CAS: 2332897-85-3
产地: 中国上海
包装: 5mg
规格: 98%
价格: 3498.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：Nav1.1 activator 1 英文名:Nav1.1 activator 1 CAS:2332897-85-3 规格:98% 产地:中国上海
您刚刚浏览过
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！