2332897-85-3
Nav1.1 activator 1
CAS: 2332897-85-3
Molecular Formula: C24H23F3N4O
2332897-85-3 - Names and Identifiers
| Name | Nav1.1 activator 1 |
| Synonyms | Nav1.1 activator 1 |
| CAS | 2332897-85-3 |
2332897-85-3 - Physico-chemical Properties
| Molecular Formula | C24H23F3N4O |
| Molar Mass | 440.46 |
| In vivo study | Nav1.1 activator 1 (compound 4) is a valuable Na v 1.1 activator for further evaluation of pathophysiological functions of the Nav1.1 channel and has potential for therapeutic treatments of CNS diseases such as Dravet syndrome. Animal Model: Mice. Dosage: 30 mg/kg ( Pharmacokinetic Analysis ). Administration: IP once (Exposure was measured at 1 h after administration). Result: Intraperitoneal administration (30 mg/kg) of compound resulted in sufficient brain exposure (193 ng/g 1 h after administration), which corresponded to 13 nM of free brain concentration comparable to the in vitro potency of the compound. Had a potential use as an in vivo tool to investigate whether this type of Na v 1.1 activator can restore Na v 1.1 functions and modify the disease state in animal models. Could penetrate the blood-brain barrier (BBB) in humans. |
