241127-58-2_化工百科

中文名	Adaphostin
英文名	Adaphostin
别名	化合物ADAPHOSTIN
英文别名	Adaphostin 1-Adamantyl 4-((2 5-Dihydroxybenzyl)Amino)Benzoate 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate 1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate 4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoicacidtricyclo[3.3.1.13,7]dec-1-ylester Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, tricyclo[3.3.1.13,7]dec-1-yl ester
CAS	241127-58-2
化学式	C24H27NO4
分子量	393.48
溶解度	DMSO: 可溶20mg/mL，澄清
存储条件	Desiccate at +4°C
外观	粉末
颜色	white to beige
产品用途	Adaphostin is a novel activator of Fas-mediated death pathway in Bcr/Abl-positive leukaemia.
WGK Germany	3
参考资料展开查看	1: Rivera-Del Valle N, Cheng T, Irwin ME, Donnella H, Singh MM, Chandra J. Combinatorial effects of histone deacetylase inhibitors (HDACi), vorinostat and entinostat, and adaphostin are characterized by distinct redox alterations. Cancer Chemother Pharmacol. 2018 Mar;81(3):483-495. doi: 10.1007/s00280-017-3509-0. Epub 2018 Jan 8. PubMed PMID: 29313067; PubMed Central PMCID: PMC5837827. 2: Fan F, Tonon G, Bashari MH, Vallet S, Antonini E, Goldschmidt H, Schulze-Bergkamen H, Opferman JT, Sattler M, Anderson KC, Jäger D, Podar K. Targeting Mcl-1 for multiple myeloma (MM) therapy: drug-induced generation of Mcl-1 fragment Mcl-1(128-350) triggers MM cell death via c-Jun upregulation. Cancer Lett. 2014 Feb 28;343(2):286-94. doi: 10.1016/j.canlet.2013.09.042. Epub 2013 Oct 8. PubMed PMID: 24120758. 3: Aguiló JI, Iturralde M, Monleón I, Iñarrea P, Pardo J, Martínez-Lorenzo MJ, Anel A, Alava MA. Cytotoxicity of quinone drugs on highly proliferative human leukemia T cells: reactive oxygen species generation and inactive shortened SOD1 isoform implications. Chem Biol Interact. 2012 Jun 25;198(1-3):18-28. doi: 10.1016/j.cbi.2012.05.001. Epub 2012 May 16. PubMed PMID: 22609468. 4: Chen YJ, Wang JJ, Chang LS. Naja nigricollis CMS-9 enhances the mitochondria-mediated death pathway in adaphostin-treated human leukaemia U937 cells. Clin Exp Pharmacol Physiol. 2011 Nov;38(11):755-63. doi: 10.1111/j.1440-1681.2011.05585.x. PubMed PMID: 21824174.

241127-58-2 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.541 ml	12.707 ml	25.414 ml
5 mM	0.508 ml	2.541 ml	5.083 ml
10 mM	0.254 ml	1.271 ml	2.541 ml
5 mM	0.051 ml	0.254 ml	0.508 ml

最后更新：2024-01-02 23:10:35

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产品名: Adaphostin 询盘
CAS: 241127-58-2
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产品名: Adaphostin 去供应商网站查看询盘
CAS: 241127-58-2
产地: 上海
规格: A936903
价格: 1mg-679,5mg-3216,25mg-16020
库存: 15天内发货
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现货供应

产品名: Adaphostin 去供应商网站查看询盘
CAS: 241127-58-2
产地: 上海
规格: 98%
价格: 5mg 1000,10mg 1600,25mg 3200,100mg 9600
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